Twenty four SNPs associated with MI in Study 1 and Study 2

*<p>1 sided P value</p

Risk factors for MI in three case–control studies

†<p>Data available for 254 cases.</p>‡<p>Individuals with diabetes were excluded from control group.</p>§<p>Dyslipidemia was defined in Study 1 and Study 2 to be self-reported history of a physician diagnosis of dyslipidemia or the use of lipid lowering prescription medication(s) and defined in Study 3 to be the use of lipid lowering prescription medication(s), LDL cholesterol >129 mg/dL, triglycerides >149 mg/dL or HDL cholesterol <45 mg/dL .</p>||<p>Hypertension was defined in Study 1 and Study 2 to be a self–reported history of a physician diagnosis of hypertension or use of antihypertensive prescription medication(s) and defined in Study 3 to be the use of antihypertensive prescription medication(s), systolic blood pressure >160 mmHg, or diastolic blood pressure >90 mmHg.</p><p>NA; not applicable.</p

Association of the SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection or Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Association of two SNPs in <i>FBN-1</i> with Thoracic Aortic Dissection.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Association of two SNPs in <i>FBN-1</i> with Non-dissecting Thoracic Aortic Aneurysm.

<p>*Adjusted for sex and study center.</p>†<p>Adjusted for sex, study center, age, hypertension, and smoking.</p

Characteristics of Dissection, Non-dissecting Aneurysm Cases, and Controls.

<p>*P value for Dissection cases vs. controls;</p>†<p>P value for Non-dissecting aneurysm cases vs. controls.</p><p>Data presented as mean ± standard deviation for age and as a number (%) of subjects for other variables.</p><p><i>P</i> values are from Fisher exact test, except those for age, which are from the Wilcoxon rank sum test.</p

Genomic region of rs13279522.

<p>A ∼500 kb region centered around rs13279522 is from UCSC browser (<a href="http://genome.ucsc.edu" target="_blank">http://genome.ucsc.edu</a>). Linkage Disequilibrium (LD) information is color-coded at the bottom, genes (horizontal blue lines) and exons (vertical blue lines) are indicated above the LD representation. Vertical orange line correspond to the negative base 10 logarithm of the P value from a case only analysis of CARE and WOSCOPS for SNPs in this region. The location of rs13279522 is indicated by a black arrow.</p

Risk reduction according to genotype for rs13279522.

<p>Risk estimate and 95% confidence intervals are indicated for each genotype group in each study, as well as for the combined analysis of the studies. The number of individuals in each group is indicated.</p

P-values from a combined case-only analysis of CARE and WOSCOPS.

<p>Panel A: A Manhattan plot of the P values from the combined case-only analysis of CARE and WOSCOPS. The x-axis corresponds to the chromosomal position for 22 chromosomes and the X chromosome. The Y axis corresponds to the negative base 10 logarithm of the P value. The red line indicates P = 10⁻⁴ and SNPs above this line are indicated in blue. Gene symbols are indicated above loci with P<10^-5 in the combined analysis of CARE and WOSCOPS. The location of DNAJC5B is also indicated. Panel B: A quantile-quantile plot of the observed vs. expected P values. The black lines indicate the 95% CI associated with the expectation that, under the hypothesis of no association, the values will fall on the red diagonal.</p

Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.

<p>Most significant SNPs associated with differential response to pravastatin therapy in a case-only combined analysis of CARE and WOSCOPS.</p