Toward “English” phonetics: variability in the pre-consonantal voicing effect across English dialects and speakers

Recent advances in access to spoken-language corpora and development of speech processing tools have made possible the performance of “large-scale” phonetic and sociolinguistic research. This study illustrates the usefulness of such a large-scale approach—using data from multiple corpora across a range of English dialects, collected, and analyzed with the SPADE project—to examine how the pre-consonantal Voicing Effect (longer vowels before voiced thanvoiceless obstruents, in e.g., bead vs. beat) is realized in spontaneous speech, and varies across dialects and individual speakers. Compared with previous reports of controlled laboratory speech, the Voicing Effect was found to be substantially smaller in spontaneous speech, but still influenced by the expected range of phonetic factors. Dialects of English differed substantially from each other in the size of the Voicing Effect, whilst individual speakers varied little relative to their particular dialect. This study demonstrates the value of large-scale phonetic research as a means of developing our understanding of the structure of speech variability, and illustrates how large-scale studies, such as those carried out within SPADE, can be applied to other questions in phonetic and sociolinguistic research

Toward “English” phonetics: variability in the pre-consonantal voicing effect across English dialects and speakers

Recent advances in access to spoken-language corpora and development of speech processing tools have made possible the performance of “large-scale” phonetic and sociolinguistic research. This study illustrates the usefulness of such a large-scale approach—using data from multiple corpora across a range of English dialects, collected, and analyzed with the SPADE project—to examine how the pre-consonantal Voicing Effect (longer vowels before voiced thanvoiceless obstruents, in e.g., bead vs. beat) is realized in spontaneous speech, and varies across dialects and individual speakers. Compared with previous reports of controlled laboratory speech, the Voicing Effect was found to be substantially smaller in spontaneous speech, but still influenced by the expected range of phonetic factors. Dialects of English differed substantially from each other in the size of the Voicing Effect, whilst individual speakers varied little relative to their particular dialect. This study demonstrates the value of large-scale phonetic research as a means of developing our understanding of the structure of speech variability, and illustrates how large-scale studies, such as those carried out within SPADE, can be applied to other questions in phonetic and sociolinguistic research

Sulfur isotopic composition of individual organic compounds from Cariaco Basin sediments

Reactions between reduced inorganic sulfur and organic compounds are thought to be important for the preservation of organic matter (OM) in sediments, but the sulfurization process is poorly understood. Sulfur isotopes are potentially useful tracers of sulfurization reactions, which often occur in the presence of a strong porewater isotopic gradient driven by microbial sulfate reduction. Prior studies of bulk sedimentary OM indicate that sulfurized products are ^(34)S-enriched relative to coexisting sulfide, and experiments have produced ^(34)S-enriched organosulfur compounds. However, analytical limitations have prevented the relationship from being tested at the molecular level in natural environments. Here we apply a new method, coupled gas chromatography – inductively coupled plasma mass spectrometry, to measure the compound-specific sulfur isotopic compositions of volatile organosulfur compounds over a 6 m core of anoxic Cariaco Basin sediments. In contrast to current conceptual models, nearly all extractable organosulfur compounds were substantially depleted in ^(34)S relative to coexisting kerogen and porewater sulfide. We hypothesize that this ^(34)S depletion is due to a normal kinetic isotope effect during the initial formation of a carbon-sulfur bond and that the source of sulfur in this relatively irreversible reaction is most likely the bisulfide anion in sedimentary pore water. The ^(34)S-depleted products of irreversible bisulfide addition alone cannot explain the isotopic composition of total extractable or residual OM. Therefore, at least two different sulfurization pathways must operate in the Cariaco Basin, generating isotopically distinct products. Compound-specific sulfur isotope analysis thus provides new insights into the timescales and mechanisms of OM sulfurization

Lifetime Risk of Lower-Extremity Peripheral Artery Disease Defined by Ankle-Brachial Index in the United States.

Background There are no available lifetime risk estimates of lower-extremity peripheral artery disease (PAD). Methods and Results Using data from 6 US community-based cohorts and the vital statistics, we estimated the prevalence and incidence of PAD, defined as an ankle-brachial index < 0.90, at each year of age from birth to 80 years for white, black, and Hispanic men and women. Then, we used Markov Monte Carlo simulations in a simulated cohort of 100 000 individuals to estimate lifetime risk of PAD. On the basis of odds ratios of PAD for traditional atherosclerotic risk factors (eg, diabetes mellitus and smoking), we developed a calculator providing residual lifetime risk of PAD. In an 80-year horizon, lifetime risks of PAD were 30.0% in black men and 27.6% in black women, but ≈19% in white men and women and ≈22% in Hispanic men and women. From another perspective, 9% of blacks were estimated to develop PAD by 60 years of age, while the same proportion was seen at ≈70 years for whites and Hispanics. The residual lifetime risk within the same race/ethnicity varied by 3.5- to 5-fold according to risk factors (eg, residual lifetime risk in 45-year-old black men was 19.9% when current smoking, diabetes mellitus, and history of cardiovascular disease were absent versus 70.4% when all were present). Conclusions In the United States, ≈30% of blacks are estimated to develop PAD during their lifetime, whereas the corresponding estimate is ≈20% for whites and Hispanics. The residual lifetime risk within the same race/ethnicity substantially varies according to traditional risk factors

Carotid Intima-Media Thickness and Incident ESRD: The Atherosclerosis Risk in Communities (ARIC) Study

Carotid intima-media thickness has been reported to predict kidney function decline. However, whether carotid intima-media thickness is associated with a hard kidney end point, ESRD, has not been investigated

Cortico-limbic morphology separates tinnitus from tinnitus distress

Tinnitus is a common auditory disorder characterized by a chronic ringing or buzzing “in the ear.”Despite the auditory-perceptual nature of this disorder, a growing number of studies have reported neuroanatomical differences in tinnitus patients outside the auditory-perceptual system. Some have used this evidence to characterize chronic tinnitus as dysregulation of the auditory system, either resulting from inefficient inhibitory control or through the formation of aversive associations with tinnitus. It remains unclear, however, whether these “non-auditory” anatomical markers of tinnitus are related to the tinnitus signal itself, or merely to negative emotional reactions to tinnitus (i.e., tinnitus distress). In the current study, we used anatomical MRI to identify neural markers of tinnitus, and measured their relationship to a variety of tinnitus characteristics and other factors often linked to tinnitus, such as hearing loss, depression, anxiety, and noise sensitivity. In a new cohort of participants, we confirmed that people with chronic tinnitus exhibit reduced gray matter in ventromedial prefrontal cortex (vmPFC) compared to controls matched for age and hearing loss. This effect was driven by reduced cortical surface area, and was not related to tinnitus distress, symptoms of depression or anxiety, noise sensitivity, or other factors. Instead, tinnitus distress was positively correlated with cortical thickness in the anterior insula in tinnitus patients, while symptoms of anxiety and depression were negatively correlated with cortical thickness in subcallosal anterior cingulate cortex (scACC) across all groups. Tinnitus patients also exhibited increased gyrification of dorsomedial prefrontal cortex (dmPFC), which was more severe in those patients with constant (vs. intermittent) tinnitus awareness. Our data suggest that the neural systems associated with chronic tinnitus are different from those involved in aversive or distressed reactions to tinnitus