Equisetum ramosissimum Desf. var. japonicum Milde

原著和名: イヌドクサ科名: トクサ科 = Equisetaceae採集地: 千葉県 夷隅郡 大原町〜岬町 三門 (上総 大原町〜岬町 三門)採集日: 1984/7/7採集者: 萩庭丈壽整理番号: JH015956国立科学博物館整理番号: TNS-VS-96595

Additional file 1: Figure S1. of Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice

Endurance exercise confers complete phenotype protection, suppresses early mortality, mitigates mitochondrial ROS-mediated oxidative damage, increases cellular antioxidant capacity, and 4 prevents cellular senescencmutator mice. Figure S2. Endurance exercise prevents dysregulated mitochondrial-induced apoptosis and reduces nuclear p53-mediated repression of PGC-1ι and promotes mitochondrial biogenesis in mutator mice. Figure S3. Endurance exercise promotes systemic mitochondrial biogenesis in mtDNA mutator mice. Figure S4. Magnitude of mitochondrial ROS (physiological vs. pathological) regulates p53 subcellular localization. Figure S5. Pre-treatment with exogenous antioxidant preferentially shuttles p53 to mitochondria in response to stress. Figure S6. Endurance exercise-mediated attenuation of sarcopenia, increase in endurance capacity, skeletal muscle mitochondrial biogenesis, and repair of muscle mtDNA mutations is p53 dependent. Table S1. WT, PolG-SED, and PolG-END Skeletal Muscle Microarray IPA-GO Analysis. Table S2. Real-time PCR primer sequences. (PDF 1601 kb