The synthesis of control (GdIII-DOTA-G5) and FA targeted dendritic chelate (GdIII-DOTA-G5-FA)

After conjugation of 4.5 (on average) of folic acid molecules to G5 PAMAM dendrimer (), 50 of the primary amine groups were acetylated (), the remaining primary amines conjugated with bifunctional NCS-DOTA () and complexed with GdCl.6HO (). The structure of the DOTA-NCS used for conjugation of contrast agents (lower panel).<p><b>Copyright information:</b></p><p>Taken from "Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement"</p><p></p><p>International Journal of Nanomedicine 2008;3(2):201-210.</p><p>Published online Jan 2008</p><p>PMCID:PMC2527674.</p><p>© 2008 Swanson et al, publisher and licensee Dove Medical Press Ltd.</p