1 research outputs found
Paraoxonase‑3 Is Depleted from the High-Density Lipoproteins of Autoimmune Disease Patients with Subclinical Atherosclerosis
Patients with autoimmune diseases
have a significantly increased
risk of developing cardiovascular disease. In disease, high-density
lipoprotein (HDL) particles lose their anti-inflammatory and antioxidant
properties and become dysfunctional. The purpose of this study was
to test the hypothesis that alterations in the HDL proteomic profile
are associated with subclinical atherosclerosis and HDL dysfunction
in patients with autoimmune diseases such as systemic lupus erythematosus
(SLE) and type 1 diabetes. Targeted proteomics was used to quantify
the relative abundance of 18 proteins in HDL from SLE patients with
and without atherosclerotic plaque detectable by carotid ultrasound.
Changes in the proteomic profile were compared against the in vitro
ability of HDL to protect against lipid oxidation. The same proteins
were quantified in HDL from patients with type 1 diabetes with or
without coronary artery calcification as determined by computed tomography.
In each population, paraoxonase-3 (PON3), a potent antioxidant protein,
was depleted from the HDL of patients with subclinical atherosclerosis.
PON3 expression in HDL was positively correlated with HDL antioxidant
function. These results suggest that PON3 may be an important protein
in preventing atherosclerosis and highlight the importance of antioxidant
proteins in the prevention of atherosclerosis in vivo