Boletín de Segovia: Número 119 - 1841 octubre 5

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 200

Additional file 1: of The effectiveness of interventions to improve laboratory requesting patterns among primary care physicians: a systematic review

PRISMA checklist. Completed PRISMA checklist indicating page number in manuscript of relevant content

Additional file 2: of General practitioners’ knowledge, attitudes and experiences of managing behavioural and psychological symptoms of dementia: protocol of a mixed methods systematic review and meta-ethnography

The MEDLINE, Ovid search strategy. (DOCX 18 kb

Additional file 1: of Case fatality ratios for serious emergency conditions in the Republic of Ireland: a longitudinal investigation of trends over the period 2002–2014 using joinpoint analysis

Table S1 Reconfiguration of emergency care systems in Ireland. (PDF 294 kb

Additional file 4: of Case fatality ratios for serious emergency conditions in the Republic of Ireland: a longitudinal investigation of trends over the period 2002–2014 using joinpoint analysis

Table S4 Events from emergency conditions used in the indicator analysis by year excluding Roscommon. (PDF 218 kb

The Schedule for the Evaluation of Individual Quality of Life (SEIQoL): a Direct Weighting procedure for Quality of Life Domains (SEIQoL-DW). Administration Manual.

The Schedule for the Evaluation of Individual Quality of Life (SEIQoL) is an interviewbased instrument for the assessment of quality of life (QoL) of the individual. The interview procedure associated with the full version of the SEIQoL (McGee et al, 1991; O’Boyle et al, 1992) requires considerable time to complete (10-20 minutes) and thus may be primarily suitable for research settings or clinical situations where the instrument is being used as part of the process of having the individual consider a range of options or outcomes in evaluating QoL. The SEIQoL has been used with a variety of patient groups, but its applicability may be limited in illnesses which impair cognitive functioning or motivational state. Successful completion of the SEIQoL requires, inter alia, insight into the factors which determine one’s quality of life, the ability to think abstractly and the ability to make judgments based on information presented in diagrammatic form. Therefore, its use with patients in whom these abilities are impaired may be problematic (Coen et al, 1993). A direct weighting procedure for QoL domains that is more suitable for routine clinical use than Judgment Analysis (JA) and that may impose fewer demands on individuals with reduced cognitive function, has been developed for the SEIQoL. Psychometric information on the procedure has been obtained from a healthy adult population (Browne et al, in preparation)

Feasibility of a multifaceted implementation intervention to improve attendance at diabetic retinopathy screening in primary care in Ireland: a cluster randomised pilot trial

Objectives: Diabetic retinopathy screening (DRS) uptake is suboptimal in many countries with limited evidence available on interventions to enhance DRS uptake in primary care. We investigated the feasibility and preliminary effects of an intervention to improve uptake of Ireland's national DRS programme, Diabetic RetinaScreen, among patients with type 1 or type 2 diabetes. Design/setting: We conducted a cluster randomised pilot trial, embedded process evaluation and cost analysis in general practice, July 2019 to January 2020. Participants: Eight practices participated in the trial. For the process evaluation, surveys were conducted with 25 staff at intervention practices. Interviews were conducted with nine staff at intervention practices, and 10 patients who received the intervention. Interventions: The intervention comprised practice reimbursement, an audit of attendance, electronic prompts targeting professionals, General Practice-endorsed patient reminders and a patient information leaflet. Practices were randomly allocated to intervention (n=4) or wait-list control (n=4) (usual care). Outcomes: Staff and patient interviews explored their perspectives on the intervention. Patient registration and attendance, including intention to attend, were measured at baseline and 6 months. Microcosting was used to estimate intervention delivery cost. Results: The process evaluation identified that enablers of feasibility included practice culture and capacity to protect time, systems to organise care, and staff skills, and workarounds to improve intervention 'fit'. At 6 months, 22/71 (31%) of baseline non-attenders in intervention practices subsequently attended screening compared with 15/87 (17%) in control practices. The total delivery cost across intervention practices (patients=363) was €2509, averaging €627 per practice and €6.91 per audited patient. Continuation criteria supported proceeding to a definitive trial. Conclusions: The Improving Diabetes Eye screening Attendance intervention is feasible in primary care; however, consideration should be given to how best to facilitate local tailoring. A definitive trial of clinical and cost-effectiveness is required with preliminary results suggesting a positive effect on uptake. Trial registration number: NCT03901898.</p

Additional file 5: of Case fatality ratios for serious emergency conditions in the Republic of Ireland: a longitudinal investigation of trends over the period 2002–2014 using joinpoint analysis

Table S5 Number of deaths and survivors by emergency conditions 2002–2014. (PDF 201 kb

A micro costing analysis of the development of a primary care intervention to improve the uptake of diabetic retinopathy screening

Background: The application of economic analysis within implementation science is still developing and the cost of intervention development, which differs markedly from the costs of initial implementation and maintenance, is often overlooked. Our aim was to retrospectively cost the development of a multifaceted intervention in primary care to improve attendance at diabetic retinopathy screening. Methods: A retrospective micro costing of developing the intervention from the research funder perspective was conducted. It was based on a systematic intervention development process involving analysis of existing audit data and interviews with patients and healthcare professionals (HCPs), conducting consensus meetings with patients and HCPs, and using these data together with a rapid review of the effectiveness of interventions, to inform the final intervention. Both direct (non-personnel, e.g. travel, stationary, room hire) and indirect (personnel) costs were included. Data sources included researcher time logs, payroll data, salary scales, an online financial management system, invoices and purchase orders. Personnel involved in the intervention development were consulted to determine the activities they conducted and the duration of their involvement. Sensitivity and scenario analyses were conducted to estimate uncertainty around parameters and scope. Results: The total cost of intervention development (July 2014-January 2019) was €40,485 of which 78% were indirect (personnel) costs (€31,451). In total, personnel contributed 1368 h to intervention development. Highest cost activities were the patient interviews, and consensus process, contributing 23% and 34% of the total cost. Varying estimated time spent on intervention development activities by + 10% increased total intervention development cost by 6% to €42,982. Conclusions: Our results highlight that intervention development requires a significant amount of human capital input, combining research experience, patient and public experience, and expert knowledge in relevant fields. The time committed to intervention development is critical but has a significant opportunity cost. With limited resources for research on developing and implementing interventions, capturing intervention development costs and incorporating them as part of assessment of cost-effective interventions, could inform research priority and resource allocation decisions.</p

Additional file 6: Table S3. of High-throughput transcriptomics reveals common and strain-specific responses of human macrophages to infection with Mycobacterium abscessus Smooth and Rough variants

Overlap of the core responses to MAB and MTB. 73 genes were identified in both datasets. “Induced” indicates that the gene shows an increase in abundance upon infection; “Repressed” indicates that the gene shows a decrease in abundance upon infection. (XLSX 8 kb