Additional file 1: of Psychometric properties of the Norwegian version of the Kidscreen-27 questionnaire

Confirmatory factor analysis conducted with Stata version 14. Page 1–4: results of model 1. Page 4–6: modification indices of model 1. Page 6–9: results of the model 2 (modified model). (PDF 330 kb

Additional file 3: of Socio-demographic determinants and effect of structured personal diabetes care: a 19-year follow-up of the randomized controlled study diabetes Care in General Practice (DCGP)

Table S2. The effect of structured personal care on behavioral, clinical, process of care and biochemical variables according to civil status (DOCX 37 kb

Additional file 5: of Socio-demographic determinants and effect of structured personal diabetes care: a 19-year follow-up of the randomized controlled study diabetes Care in General Practice (DCGP)

Table S4. The effect of structured personal care on behavioral, clinical, process of care and biochemical variables according to residence (Rural vs. Urban) (DOCX 37 kb

Additional file 1: of Socio-demographic determinants and effect of structured personal diabetes care: a 19-year follow-up of the randomized controlled study diabetes Care in General Practice (DCGP)

Definition of clinical outcomes in the 19-year registry-based monitoring of the DCGP study, any diabetes related endpoint (list). (DOCX 76 kb

Spontaneous clotting occurrence in plasma of patients with various disorders.

<p>Spontaneous clotting occurrence in plasma of patients with various disorders.</p

The role of TF, factors IXa, and XIa in spontaneous clotting.

<p>(A) Clot growth images from thrombodynamics assay in four versions: a patient PFP without any inhibitors, the same plasma after addition of 0.1 mg/ml inhibiting monoclonal antibody to fXI, after addition of 10 nM Nitrophorin2, fIX inhibitor, after addition of 50 nM VIIai, TF inhibitor. (B) Mean 1/T_0.1±se in plasma samples of eight patients according to described four experiment versions.</p

Stability of natural SC and SC induced by addition of factors IXa and Xia.

<p>Dependence 1/T_0.1 of storage time in plasma from four patients. Different symbols correspond to different patients (A). The same dependence in healthy donors’ plasma with addition of 75 pM of fIXa (B) and 150 pM of fXIa (C). T_0.1 is normalized to the T_0.1 first-point plasma value.</p

Plasma samples with SC in thrombodinamics and in thrombin generation assays.

<p>(A) Photographs of clot growth in normal donor platelet free plasma and in plasma enriched with vesicles 3.3-fold. (B) AMC generation curves in PFP (filled symbols) and microparticles rich plasma (MRP) (empty symbols) of 3 normal donors activated by 5 pM TF. (C) Average±se thrombin generation curves in normal donors’ platelet free plasma (PFP) and MRP for 3 donors. (D) Thrombin generation curves for 6 patients with SC in thrombodinamics assay and average thrombin generation curves in normal donors PFP and MRP. In C and D thrombin generation was started with racalcification. No external activator was added.</p

Active factors influence on thrombodinamics.

<p>(A) Spontaneous clotting patterns after active factors addition. (B) Clot growth rate distributions in patients’ plasma with SC and without. (C) Relative clot growth rate change after active factors and procoagulant zymogens addition to normal donors’ plasma. Concentrations of supplemented factors and number of donors are shown in table below the histograme.</p

The role of microparticles and phospholipid surface in spontaneous clotting.

<p>Representative patterns of clotting in plasma cleared from microparticles by centrifugation 30(A) (n = 5) or not(B) (n = 17) and in normal plasma supplemented with fXIa (C).</p