20 research outputs found
Large cerebello-pontine epidermoid tumor in a child
Cerebellopontine angle lesions are more commonly found in adults; however, they are uncommon in children. 13 year female child presented with progressive cerebellar signs and decreased hearing in left ear. Magnetic resonance imaging was suggestive of left cerebello-pontine angle epidermoid tumor that was treated surgically. In this rare case we discuss the imaging findings and review the relevant literature
Modulation of morphology and efficacy of new CB1 receptor antagonist using simple and benign polymeric additives
1014-1021The compound 1, [(1H-[1]benzoxepino[5,4-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-4,5-dihydro-N-
1-piperidinyl], a known CB1 modulator has been synthesized and characterized by IR, NMR and single Crystal X-ray study.
The single crystal study of 1 displays a number of halogen bonds leading to 1-D network along with other weak noncovalent
interactions. The CB1 modulator 1 inherently possesses extremely low solubility in water, which makes its
application as drug difficult, and this may be attributed to multiple halogen bonds present in the crystal structure. A series of
polymer additives, which are Generally Regarded As Safe (GRAS), have been explored to investigate whether they can
modulate the halogen bond present in 1 through formation of various non-bonded interactions. Surprisingly, these polymers
are found to change crystal morphology, crystal packing while retaining efficacy and bioavailability. The polymer molecular
weight is found to play a significant role in crystal morphology modification especially in case of polyethylene glycol
(PEG). The formation of new polymorphic forms of 1 and modification of halogen bond has been established using powder
X-ray diffraction and IR study, respectively, in case of PEG 4000, PVPK-30, PVA polymers and compound 1 adducts
Modulation of morphology and efficacy of new CB1 receptor antagonist using simple and benign polymeric additives
The compound 1, [(1H-[1]benzoxepino[5,4-c]pyrazole-3-carboxamide, 8-chloro-1-(2,4-dichlorophenyl)-4,5-dihydro-N-1-piperidinyl], a known CB1 modulator has been synthesized and characterized by IR, NMR and single Crystal X-ray study. The single crystal study of 1 displays a number of halogen bonds leading to 1-D network along with other weak non-covalent interactions. The CB1 modulator 1 inherently possesses extremely low solubility in water, which makes its application as drug difficult, and this may be attributed to multiple halogen bonds present in the crystal structure. A series of polymer additives, which are Generally Regarded As Safe (GRAS), have been explored to investigate whether they can modulate the halogen bond present in 1 through formation of various non-bonded interactions. Surprisingly, these polymers are found to change crystal morphology, crystal packing while retaining efficacy and bioavailability. The polymer molecular weight is found to play a significant role in crystal morphology modification especially in case of polyethylene glycol (PEG). The formation of new polymorphic forms of 1 and modification of halogen bond has been established using powder X-ray diffraction and IR study, respectively, in case of PEG 4000, PVPK-30, PVA polymers and compound 1 adducts.
Giant Asterional Dermoid Cyst with Dermal Sinus; a Case Report
Background: Dermoid cyst with dermal sinus in occipital region is
extremely rare occurrence and still rarer in asterion region. We report
a case of dermoid cyst with dermal sinus at the asterion probably the
second case of world literature and discuss the findings. Case
Presentation: 16 year-old female patient with mental retardation and
inability to speak since childhood presented with history of
progressive increasing swelling since childhood over the left side of
occipital region. Local examination and investigations were suggestive
of extracranial cystic lesion. The lesion was excised completely. When
excision of such lesions is contemplated, careful attention must be
paid during exploration. Conclusion: Failure to recognize
intracranial communication in such lesions may result in fatal
consequences. Pre-operative suspicion of such a connection helped us to
identify the underlying defect intra-operatively and facilitated safe
excision
Tecto-Cerebellar Dysraphia Manifesting as Occipital Meningocoele Associated with Congenital Melanocytic Nevi and Pectus Excavatum
Background: Only few reported cases of tectocerebellar dysraphia with
occipital encephalocele have been reported in the literature. Case
Presentation: Three month baby boy, the first child of healthy,
consanguineous parents presented with a small swelling over the
occipital region since birth. The child also used to have apneic spells
without cyanosis and spontaneous recovery. CT scan showed absence of
the cerebellar vermis, absence of tectum and the 4th ventricle
communicating with the occipital menigocoele sac and an occipital bone
defect. The excision of the encephalocoele sac was performed, however
the child continued to have apneic spells and did not do well.
Conclusion: In our child irregular respiration probably was the
manifestation of the tecto-cerebellar dysraphia syndrome complex and
associated shunt malfunction followed by seizures decompensated the
physiology of the child leading to fatal outcome