ANALISIS PENGGUNAAN ADVERBIA ZUIBUN, KANARI DAN KEKKOU DALAM KALIMAT BAHASA JEPANG 日本語の副詞「ずいぶん」「かなり」「けっこう」の意味使用

ABSTRACT Johanes. “The use and meaning adverbs of Zuibun, Kanari, and Kekkou in Japanese Sentences”. Thesis. Departement of Japanese Studies Faculty of Humanities. Diponegoro University. The First Advisor Reny Wiyatasari SS, M.Hum, The Second Advisor Maharani Patria Ratna, SS, M.Hum. The purpose of this research are to analyze the meaning and the use of zuibun, kanari and kekkou. Not only that, the research also aims to find out the relation between those adverbs whether they can substitute each other or not. After analyzing the adverbs zuibun, kanari and kekkou which were divided into two parts, the meaningof a circumstance which is above the average and a little above the average. Those three adverbs have different strength levels within a word. The adverbs zuibun has the highest level compared to the two others adverbs. Then adverbs kanari rank second in the stage making kekkou end up as the last. The adverbs zuibun, kanari and kekkou can be used both in spoken language and in written language, but in the implementation, create different nuances. Thus the three adverbs are interchangeable. Keyword: substituted, adverb, zuibun, kanari, kekkou

Penggunaan COBIT 4.1 Dengan Domain ME Pada Sistem Informasi Absensi (Studi Kasus: Universitas XYZ)

Berkembangnya teknologi informasi dalam berbagai aspek kehidupan manusia membuat teknologi informasi menjadi kunci penting dalam sebuah perusahaan dan lembaga. Penggunaan layanan informasi tersebut dapat dilihat salah satunya pada proses absensi. Universitas XYZ merupakan salah satu lembaga yang menggunakan layanan teknologi informasi dalam proses absensi. Proses absensi Universitas XYZ dilakukan dengan cara fingerprint dan telah diterapkan dalam jangka waktu yang lama. Dalam penelitian kali ini, peneliti akan melakukan audit terhadap proses pengawasan dan evaluasi yang dilakukan Universitas XYZ terhadap proses kinerja absensi fingerprint tersebut apakah telah berjalan secara baik dan efektif dengan menggunakan framework COBIT 4.1 pada domain ME (Monitoring and Evaluation) sehingga semua analisis audit yang dilakukan sesuai dengan standar yang ada pada framework tersebut. Hasil penelitian akan menunjukkan tingkat pengawasan dan evaluasi serta kesimpulan yang didapatkan terhadap absensi yang berada di Universitas XYZ telah sesuai dengan standar framework COBIT 4.1

Reducing Premature Coronary Artery Disease in Malaysia by Early Identification of Familial Hypercholesterolemia Using the Familial Hypercholesterolemia Case Ascertainment Tool (FAMCAT): Protocol for a Mixed Methods Evaluation Study

Background:Familial hypercholesterolemia (FH) is predominantly caused by mutations in the 4 FH candidate genes (FHCGs), namely, low-density lipoprotein receptor (LDLR), apolipoprotein B-100 (APOB-100), proprotein convertase subtilisin/kexin type 9 (PCSK9), and the LDL receptor adaptor protein 1 (LDLRAP1). It is characterized by elevated low-density lipoprotein cholesterol (LDL-c) levels leading to premature coronary artery disease. FH can be clinically diagnosed using established clinical criteria, namely, Simon Broome (SB) and Dutch Lipid Clinic Criteria (DLCC), and can be identified using the Familial Hypercholesterolemia Case Ascertainment Tool (FAMCAT), a primary care screening tool.Objective:This study aims to (1) compare the detection rate of genetically confirmed FH and diagnostic accuracy between the FAMCAT, SB, and DLCC in the Malaysian primary care setting; (2) identify the genetic mutation profiles, including novel variants, in individuals with suspected FH in primary care; (3) explore the experience, concern, and expectation of individuals with suspected FH who have undergone genetic testing in primary care; and (4) evaluate the clinical utility of a web-based FH Identification Tool that includes the FAMCAT, SB, and DLCC in the Malaysian primary care setting.Methods:This is a mixed methods evaluation study conducted in 11 Ministry of Health primary care clinics located at the central administrative region of Malaysia. In Work stream 1, the diagnostic accuracy study design is used to compare the detection rate and diagnostic accuracy of the FAMCAT, SB, and DLCC against molecular diagnosis as the gold standard. In Work stream 2, the targeted next-generation sequencing of the 4 FHCGs is used to identify the genetic mutation profiles among individuals with suspected FH. In Work stream 3a, a qualitative semistructured interview methodology is used to explore the experience, concern, and expectation of individuals with suspected FH who have undergone genetic testing. Lastly, in Work stream 3b, a qualitative real-time observation of primary care physicians using the “think-aloud” methodology is applied to evaluate the clinical utility of a web-based FH Identification Tool.Results:The recruitment for Work stream 1, and blood sampling and genetic analysis for Work stream 2 were completed in February 2023. Data collection for Work stream 3 was completed in March 2023. Data analysis for Work streams 1, 2, 3a, and 3b is projected to be completed by June 2023, with the results of this study anticipated to be published by December 2023.Conclusions:This study will provide evidence on which clinical diagnostic criterion is the best to detect FH in the Malaysian primary care setting. The full spectrum of genetic mutations in the FHCGs including novel pathogenic variants will be identified. Patients’ perspectives while undergoing genetic testing and the primary care physicians experience in utilizing the web-based tool will be established. These findings will have tremendous impact on the management of patients with FH in primary care and subsequently reduce their risk of premature coronary artery disease.International Registered Report Identifier (IRRID):DERR1-10.2196/4791