Multivariate analysis (adjusted for age, gender, race, and all of the risk factors in the table) of associations of left ventricular (LV) structure/function and aortic function versus risk factors (beta and * for p < 0.05).

<p>Multivariate analysis (adjusted for age, gender, race, and all of the risk factors in the table) of associations of left ventricular (LV) structure/function and aortic function versus risk factors (beta and * for p < 0.05).</p

Comparison of LV indices between study subjects with versus without cardiovascular risk factors.

<p>Percent difference [100×(with-risk−risk-free) ⁄ risk-free] are shown. All displayed indices are significantly different between with-risk and risk-free groups.</p

Left-ventricular mass index by body surface area and mass to volume (M/V) ratio of risk-free and with risk MESA participants stratified by gender and race.

<p>Values displayed as mean±SD (95% confidence interval). * p<0.05 of the unpaired t-test between black and white in the corresponding category.</p

The relationship of age with left-ventricular (LV) structure/function and aortic function in men and women with and without traditional risk factors.

<p>Univariate regression coefficient which represents change in the dependent variable per one-year increase in age. * for p<0.05.</p

The relationship of age with left-ventricular (LV) structure/function and aortic function stratified by with and without traditional risk factors and race/ethnicity.

<p>Univariate regression coefficient which represents change in the dependent variable per one-year increase in age. * for p<0.05.</p

Left-ventricular (LV) structure/function and aortic function of risk-free and with risk MESA participants.

<p>Values displayed as mean±SD (95% confidence interval) and * for p<0.05 between groups after multivariate adjustment for age/sex/race.</p

Healthy aging of the left ventricle in relationship to cardiovascular risk factors: The Multi-Ethnic Study of Atherosclerosis (MESA) - Fig 2

<p>(A) LV EDV index is inversely associated with age in all groups. (B) LV mass index in women without risk factors was independent of age. M/V ratio was positively (C) and stroke volume index (D) was inversely associated with age but both changes are not significant in men without risk factors.</p

Associations between high affinity^‡ SSRI use and RV measures in limited and adjusted models, stratified by sex for RV mass and RVEDV.

<p>*Adjusted for age, sex, race/ethnicity, height, weight, and level of education.</p>†<p>Adjusted for age, sex, race/ethnicity, height, weight, level of education, depression (Center for Epidemiologic Studies Depression-Scale (CES-D) ≥16), smoking (status and pack-years), hypertension, systolic and diastolic blood pressure, cholesterol, low-density lipoprotein levels, triglycerides, and statin use.</p>‡<p>Fluoxetine, fluvoxamine, paroxetine, and sertraline.</p

Associations between SSRI use and RV measures in limited and adjusted models, stratified by sex for RV mass and RVEDV.

<p>*Adjusted for age, sex, race/ethnicity, height, weight, and level of education.</p>†<p>Adjusted for age, sex, race/ethnicity, height, weight, level of education, depression (Center for Epidemiologic Studies.</p><p>Depression-Scale (CES-D) ≥16), smoking (status and pack-years), hypertension, systolic and diastolic blood pressure, cholesterol, low-density lipoprotein levels, triglycerides, and statin use.</p

Characteristics of the study sample and of those participants excluded.

<p>Data shown as mean ± standard deviation or %. Percentages may not add to one because of rounding.</p><p>*Citalopram.</p>†<p>Fluoxetine, fluvoxamine, paroxetine, and sertraline.</p>‡<p>Includes atypical (bupropion), monoamine oxidase inhibitors, tetracyclic (mirtazapine), and serotonin antagonist and reuptake inhibitor (trazodone and nefazodone) antidepressants.</p