PMN cell numbers and IL-1β and MIP2 concentrations are plotted as a function of different characteristics of the instilled UFPs: () primary particle diameter (for an exemplary dose of 20 μg); () OC mass; and () particle surface area (BET)

<p><b>Copyright information:</b></p><p>Taken from "Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice"</p><p>Environmental Health Perspectives 2005;114(3):328-333.</p><p>Published online 22 Sep 2005</p><p>PMCID:PMC1392224.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p> Each symbol represents mean values of eight animals. A regression analysis revealed a strong logarithmic relation for the surface area ( = 0.65) and a weaker relation for the organic contribution ( = 0.38)

Threshold for inflammatory response for ufCP shown as the correlation between particle surface area and PMN cell numbers () or IL-1β () or MIP2 () concentrations

<p><b>Copyright information:</b></p><p>Taken from "Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice"</p><p>Environmental Health Perspectives 2005;114(3):328-333.</p><p>Published online 22 Sep 2005</p><p>PMCID:PMC1392224.</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p> Two additional instilled doses of 0.5 and 2 μg, together with 5, 20, and 50 μg ufCP represent BET surface areas of 0.4, 16, 40, 161, and 404 cm, respectively. The dashed line indicates baseline levels of control animals; each circle represents the mean of eight animals