Additional file 1 of Effect of an increase in Lp(a) following statin therapy on cardiovascular prognosis in secondary prevention population of coronary artery disease

Additional file 1: Table S1. Statins used in study subjects. Table S2. Endpoint events for study subjects. Table S3. Univariate COX analysis of risk factors for MACE

The Prognostic and Clinicopathological Significance of Tumor-Associated Macrophages in Patients with Gastric Cancer: A Meta-Analysis

<div><p>Objective</p><p>Comprehensive studies have investigated the prognostic and clinicopathological value of tumor-associated macrophages (TAMs) in gastric cancer patients, yet results remain controversial. Therefore, we performed a meta-analysis to clarify this issue.</p><p>Methods</p><p>PubMed, Embase, and the Cochrane Library databases were searched to identify eligible studies. We extracted hazard ratios (HRs) and odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) to estimate the effect sizes. In addition, subgroup analysis and sensitivity analysis were also conducted.</p><p>Results</p><p>A total of 19 studies involving 2242 patients were included. High generalised TAMs density was significantly associated with poor overall survival (OS) (HR 1.49, 95% CI 1.15–1.95). Subgroup analysis revealed that CD68⁺ TAMs had no significant effect on OS (HR 1.38, 95% CI 1.00–1.91). High M1 TAMs density was correlated with better OS (HR 0.45, 95% CI 0.32–0.65). By contrast, high density of M2 TAMs was correlated with a poor prognosis for OS (HR 1.48, 95% CI 1.25–1.75). Furthermore, high M2 TAMs density was correlated with larger tumor size, diffuse Lauren type, poor histologic differentiation, deeper tumor invasion, lymph node metastasis, and advanced TNM stage.</p><p>Conclusions</p><p>Overall, this meta-analysis reveal that although CD68⁺ TAMs infiltration has the neutral prognostic effects on OS, the M1/M2 polarization of TAMs are predicative factor of prognosis in gastric cancer patients.</p></div

Sensitivity analysis of TAMs on OS and funnel plots of publication bias in analysis of OS.

<p>(A) Sensitivity analysis of generalised TAMs. (B) Sensitivity analysis of CD68⁺ TAMs. (C) Sensitivity analysis of M2 TAMs. (D) Funnel plot for generalised TAMs on OS. (E) Funnel plot for CD68⁺ TAMs. (F) Funnel plot for M2 TAMs.</p

The relationship between TAMs and clinicopathological characteristics.

<p>The relationship between TAMs and clinicopathological characteristics.</p

Forest plots of HRs for the correlation between TAMs density and OS.

<p>(A) Generalized TAMs. (B) CD68⁺ TAMs. (C) M1 TAMs. (D) M2 TAMs.</p

Forest plots of HRs for the correlation between TAMs density and DFS.

<p>(A) Intratumor CD68⁺ TAMs. (B) Stroma CD68⁺ TAMs. (C) Intratumor M2 TAMs. (D) Stroma M2 TAMs.</p

Flow chart of the study selection process.

<p>Flow chart of the study selection process.</p

Table1_Impact of epicardial adipose tissue volume on hemodynamically significant coronary artery disease in Chinese patients with known or suspected coronary artery disease.docx

BackgroundEpicardial adipose tissue (EAT) is directly related to coronary artery disease (CAD), but little is known about its role in hemodynamically significant CAD. Therefore, our goal is to explore the impact of EAT volume on hemodynamically significant CAD.MethodsPatients who underwent coronary computed tomography angiography (CCTA) and received coronary angiography within 30 days were retrospectively included. Measurements of EAT volume and coronary artery calcium score (CACs) were performed on a semi-automatic software based on CCTA images, while quantitative flow ratio (QFR) was automatically calculated by the AngioPlus system according to coronary angiographic images.ResultsThis study included 277 patients, 112 of whom had hemodynamically significant CAD and showed higher EAT volume. In multivariate analysis, EAT volume was independently and positively correlated with hemodynamically significant CAD [per standard deviation (SD) cm3; odds ratio (OR), 2.78; 95% confidence interval (CI), 1.86–4.15; P min (per SD cm3; β coefficient, −0.068; 95% CI, −0.109 to −0.027; P = 0.001) after adjustment for traditional risk factors and CACs. Receiver operating characteristics curve analysis demonstrated a significant improvement in predictive value for hemodynamically significant CAD with the addition of EAT volume to obstructive CAD alone (area under the curve, 0.950 vs. 0.891; P ConclusionIn this study, we found that EAT volume correlated substantially and positively with the existence and severity of hemodynamically significant CAD in Chinese patients with known or suspected CAD, which was independent of traditional risk factors and CACs. In combination with obstructive CAD, EAT volume significantly improved diagnostic performance for hemodynamically significant CAD, suggesting that EAT could be a reliable noninvasive indicator of hemodynamically significant CAD.</p

Additional file 3: of Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Table S2. Summary of the number of samples deposited in the biobank obtained from the heavy-metal cohort (MEWHC) initiated in 2011. (PDF 89 kb

Additional file 1: of Follow-up of the manganese-exposed workers healthy cohort (MEWHC) and biobank management from 2011 to 2017 in China

Table S1. Air monitoring of different workshops and jobs in the ferro-Mn alloy production plant in 2017. (PDF 107 kb