2 research outputs found
Notolutesins A–J, Dolabrane-Type Diterpenoids from the Chinese Liverwort <i>Notoscyphus lutescens</i>
Ten new dolabrane-type diterpenoids,
notolutesins A–J (<b>1</b>–<b>10</b>), were
isolated from the Chinese liverwort <i>Notoscyphus lutescens</i>, along with four known compounds. The structures of the new compounds
were established on the basis of extensive spectroscopic data, and
that of <b>1</b> was confirmed by single-crystal X-ray crystallography.
The absolute configuration of <b>1</b> was determined by comparing
its experimental and calculated electronic circular dichroism spectra.
All of the isolates were evaluated for their cytotoxicity against
a small panel of human cancer cell lines, and compound <b>1</b> exhibited an IC<sub>50</sub> value of 6.2 μM against the PC3
human prostate cancer cell line
Notolutesins A–J, Dolabrane-Type Diterpenoids from the Chinese Liverwort <i>Notoscyphus lutescens</i>
Ten new dolabrane-type diterpenoids,
notolutesins A–J (<b>1</b>–<b>10</b>), were
isolated from the Chinese liverwort <i>Notoscyphus lutescens</i>, along with four known compounds. The structures of the new compounds
were established on the basis of extensive spectroscopic data, and
that of <b>1</b> was confirmed by single-crystal X-ray crystallography.
The absolute configuration of <b>1</b> was determined by comparing
its experimental and calculated electronic circular dichroism spectra.
All of the isolates were evaluated for their cytotoxicity against
a small panel of human cancer cell lines, and compound <b>1</b> exhibited an IC<sub>50</sub> value of 6.2 μM against the PC3
human prostate cancer cell line