1 research outputs found
One-Pot Approach to 1,2-Disubstituted Indoles via Cu(II)-Catalyzed Coupling/Cyclization under Aerobic Conditions and Its Application for the Synthesis of Polycyclic Indoles
A straightforward
assembly of 1,2-disubstituted indoles has been
developed through a CuÂ(II)-catalyzed domino coupling/cyclization process.
Under aerobic conditions, a wide range of 1,2-disubstituted indole
derivatives were efficiently and facilely synthesized from 2-alkynylanilines
and boronic acids. 2-(2-Bromoaryl)-1-aryl-1<i>H</i>-indoles,
which were selectively generated in one pot under the Cu catalysis,
afforded the indoloÂ[1,2-<i>f</i>]Âphenanthridines via Pd-catalyzed
intramolecular direct CÂ(sp<sup>2</sup>)–H arylation. The one-pot
tandem approaches to the polycyclic indole derivatives were also successfully
achieved