1 research outputs found
Peniphenones A–D from the Mangrove Fungus <i>Penicillium dipodomyicola</i> HN4-3A as Inhibitors of <i>Mycobacterium tuberculosis</i> Phosphatase MptpB
A pair of unusual benzannulated 6,6-spiroketal
enantiomers [(−)-<b>1</b> and (+)-<b>1</b>] and
three new biogenetically related compounds (<b>2</b>–<b>4</b>), together with two known related analogues (<b>5</b> and <b>6</b>), have been isolated from a mangrove fungus, <i>Penicillium dipodomyicola</i> HN4-3A. Their structures were
elucidated on the basis of spectroscopic analysis (1D and 2D NMR data)
and X-ray crystallography. The absolute configurations of enantiomers
(−)-<b>1</b> and (+)-<b>1</b> were determined using
quantum chemical calculations of the electronic circular dichroic
(ECD) spectra. Compounds <b>2</b> and <b>3</b> exhibited
strong inhibitory activity against <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B (MptpB) with IC<sub>50</sub> values
of 0.16 ± 0.02 and 1.37 ± 0.05 μM, respectively