Cytoplasmic DNAs: Sources, sensing, and roles in the development of lung inflammatory diseases and cancer

Cytoplasmic DNA is emerging as a pivotal contributor to the pathogenesis of inflammatory diseases and cancer, such as COVID-19 and lung carcinoma. However, the complexity of various cytoplasmic DNA-related pathways and their crosstalk remains challenging to distinguish their specific roles in many distinct inflammatory diseases, especially for the underlying mechanisms. Here, we reviewed the latest findings on cytoplasmic DNA and its signaling pathways in inflammatory lung conditions and lung cancer progression. We found that sustained activation of cytoplasmic DNA sensing pathways contributes to the development of common lung diseases, which may result from external factors or mutations of key genes in the organism. We further discussed the interplays between cytoplasmic DNA and anti-inflammatory or anti-tumor effects for potential immunotherapy. In sum, this review aids in understanding the roles of cytoplasmic DNAs and exploring more therapeutic strategies

State and Market in Socialist Development: the case of Chinese industrial planning

SUMMARY This article examines the capacities and limits of the socialist state as an instrument of industrialisation in China. Chinese experience suggests that state involvement at all stages of socialist industrialisation should become more selective in its scope and more flexible in its managerial forms. It highlights the importance of developing a lively industrial microeconomy and striking a balance between state agencies and industrial enterprises. RESUMEN Estado y mercado en el desarrollo socialista: el caso de la planificación industrial china. Este articulo examina la capacidad y límites del estado socialista como instrumento de industrialización en China. La experiencia de este país sugiere que la participación estatal en todas las etapas de la industrialización socialista, debería ser más selectiva en su campo de acción y más flexible en sus formas administrativas. Subraya la importancia de desarrollar una microeconomía industrial dinámica y de lograr un equilibrio entre las agencias estatales y las empresas industriales. RESUMES Etat et marché dans le développement socialiste: le cas de la planification industrielle en Chine Cet article examine les capacités et les limites de l'état socialiste en tant qu'instrument d'industrialisation en Chine. L'expérience chinoise suggère que l'implication de l'état à tous les niveaux de l'industrialisation socialiste devrait devenir plus sélective dans son but et plus flexible dans ses formes directoriales. Elle souligne l'importance de développer une micróeconomie industrielle bien vivante et d'établir un équilibre entre les agences d'état et les entreprises industrielles

Plio-Pleistocene establishment of Irtysh River in Junggar, Northwest China: implications for Siberian-Arctic river system evolution and resulting climate impact

The influence of Siberian freshwater input to the Arctic Ocean on Northern Hemisphere ice-sheet expansions remains poorly known due to the incomplete geologic record of Siberian-Arctic river systems during the late Pliocene. The Irtysh River is a major Siberian river, rising from the Altay Mountains, northwestern China, and flowing 4,282 km before joining the Ob River. Here, we present new field evidence and chronological data from a combination of cosmogenic 21Ne and 26Al/10Be measurements that constrain the establishment of the Irtysh River to ca. 2.77+0.39/-0.33 Ma. These first quantitative chronological results, together with previous sedimentological, geomorphological, and geochemical evidence, support a young Siberian-Arctic river system. Its coincidence with the late Pliocene ice-sheet expansions in the Northern Hemisphere implies a profound impact of Siberian freshwater input to the Arctic on the major ice advances that significantly affected global oceanographic and climatic systems

A High-Performance Soy Protein Isolate-Based Nanocomposite Film Modified with Microcrystalline Cellulose and Cu and Zn Nanoclusters

Soy protein isolate (SPI)-based materials are abundant, biocompatible, renewable, and biodegradable. In order to improve the tensile strength (TS) of SPI films, we prepared a novel composite film modified with microcrystalline cellulose (MCC) and metal nanoclusters (NCs) in this study. The effects of the modification of MCC on the properties of SPI-Cu NCs and SPI-Zn NCs films were investigated. Attenuated total reflectance-Fourier transformed infrared spectroscopy analyses and X-ray diffraction patterns characterized the strong interactions and reduction of the crystalline structure of the composite films. Scanning electron microscopy (SEM) showed the enhanced cross-linked and entangled structure of modified films. Compared with an untreated SPI film, the tensile strength of the SPI-MCC-Cu and SPI-MCC-Zn films increased from 2.91 to 13.95 and 6.52 MPa, respectively. Moreover, the results also indicated their favorable water resistance with a higher water contact angle. Meanwhile, the composite films exhibited increased initial degradation temperatures, demonstrating their higher thermostability. The results suggested that MCC could effectively improve the performance of SPI-NCs films, which would provide a novel preparation method for environmentally friendly SPI-based films in the applications of packaging materials

Logistic Regression at TREC4: s Probabilistic Retrieval from Full Text Document Collection

l w The Berkeley experiments for TREC4 extend those of TREC3 in three ways: for ad-hoc retrieva e retain the manual reformulations of the topics and experiment with limited query expansion g f based upon the assumption that top documents are relevant (this experiment was an interestin ailure); for routing retrieval we introduce a logistic regression which assumes relevance weights to h r be only one clue among several in predicting probability of relevance. Finally, for Spanis etrieval we retrain the basic logistic regression equations to apply to the statistical distributions of r Spanish words. In addition we apply two approaches to Spanish stemming, one which attempts to esolve verb variants into a standardized form, the other of which eschews stemming in favor of a 1 massive stop word list of variants of common words. . Introduction and history of Berkeley TREC participation For the past several years the UC Berekd ley Text Retrieval Research Group has been eveloping an approac..

Exploring Park Visit Variability Using Cell Phone Data in Shenzhen, China

Exploring the spatiotemporal characteristics of park visitors and the “push and pull” factors that shape this mobility is critical to designing and managing urban parks to meet the demands of rapid urbanization. In this paper, 56 parks in Shenzhen were studied in 2019. First, cell phone signaling data were used to extract information on visitors’ departure locations and destination parks. Second, the bivariate Moran’s I and bivariate local Moran’s I (BiLISA) methods were used to identify the statistical correlation between the factors of the built environment and the park recreation trips. Finally, linear regression models were constructed to quantify the factors influencing the attractiveness of the park. Our study showed the following: (1) Recreation visitors at large parks varied significantly among population subgroups. Compared with younger adults, teenagers and older adults traveled lower distances and made fewer trips, and in particular, older adults of different genders differed significantly in park participation. (2) Recreational trips in large parks were related to the functional layout of the built environment around their residence. In areas with rich urban functions (e.g., southern Shenzhen), trips to large parks for leisure are more aggregated. (3) The findings reinforce the evidence that remote sensing data for urban vegetation can be an effective factor in characterizing park attractiveness, but the explanatory power of different vegetation data varies widely. Our study integrated the complementary human activity and remote sensing data to provide a more comprehensive understanding of urban park use and preferences. This will be important for future park planning

Term importance, Boolean conjunct training, negative terms, and foreign language retrieval: probabilistic algorithms at TREC-5

The Berkeley experiments for TREC-5 extend those of TREC-4 in numerous ways. For routing retrieval we experimented with the idea of term importance in three ways -- training on Boolean conjuncts of the most important terms, filtering with the most important terms, and, finally, logistic regression on presence or absence of those terms. For ad-hoc retrieval we retained the manual reformulations of the topics and experimented with negative query terms. The ad-hoc retrieval formula originally devised for TREC-2 has proven to be robust, and was used for the TREC-5 ad-hoc retrieval and for our Chinese and Spanish retrieval. Chinese retrieval was accomplished through development of a segmentation algorithm which was used to augment a Chinese dictionary. The manual query run BrklyCH2 achieved a spectacular 97.48 percent recall over the 19 queries evaluated before the conference. 1. Introduction From the beginning of the TREC conference series, the UC Berkeley Text Retrieval Research Group ha..