Colletotrichine B, a new sesquiterpenoid from <i>Colletotrichum gloeosporioides</i> GT-7, a fungal endophyte of <i>Uncaria rhynchophylla</i>

<p>One new compound, colletotrichine B (<b>1</b>), was produced by the fungal <i>Colletotrichum gloeosporioides</i> GT-7. The structure of <b>1</b> was elucidated on the basis of spectroscopic analysis and X-ray crystallographic analysis. Monoamine oxidase (MAO), acetylcholinesterase (AChE) and phosphoinositide 3-kinase (PI3Kα) inhibitory activity of <b>1</b> was also evaluated. Compound <b>1</b> showed only AChE inhibiting activity with IC₅₀ value of 38.0 ± 2.67 μg/mL.</p