Direct Detection of Planets Orbiting Large Angular Diameter Stars: Sensitivity of an Internally Occulting Space-based Coronagraph

High-contrast imaging observations of large angular diameter stars enable complementary science questions to be addressed compared to the baseline goals of proposed missions like the Terrestrial Planet Finder-Coronagraph, New World's Observer, and others. Such targets, however, present a practical problem in that finite stellar size results in unwanted starlight reaching the detector, which degrades contrast. In this paper, we quantify the sensitivity, in terms of contrast, of an internally occulting, space-based coronagraph as a function of stellar angular diameter, from unresolved dwarfs to the largest evolved stars. Our calculations show that an assortment of band-limited image masks can accommodate a diverse set of observations to help maximize mission scientific return. We discuss two applications based on the results: the spectro-photometric study of planets already discovered with the radial velocity technique to orbit evolved stars, which we elucidate with the example of Pollux b, and the direct detection of planets orbiting our closest neighbor, α Centauri, whose primary component is on the main sequence but subtends an appreciable angle on the sky. It is recommended that similar trade studies be performed with other promising internal, external, and hybrid occulter designs for comparison, as there is relevance to a host of interesting topics in planetary science and related fields

Typing tumors using pathways selected by somatic evolution.

Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to cancer or the patient's tumor type, as these interactions diminish the contrast of driver pathways relative to individual frequently mutated genes. This problem can be addressed by creating stringent tumor-specific networks of biophysical protein interactions, identified by signatures of epistatic selection during tumor evolution. Using such an evolutionarily selected pathway (ESP) map, we analyze the major cancer genome atlases to derive a hierarchical classification of tumor subtypes linked to characteristic mutated pathways. These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. This ESP framework substantially improves the definition of cancer pathways and subtypes from tumor genome data

Eighth-Order Image Masks for Terrestrial Planet Finding

We describe a new series of band-limited image masks for coronagraphy that are insensitive to pointing errors and other low-spatial-frequency optical aberrations. For a modest cost in throughput, these ``eighth-order'' masks would allow the Terrestrial Planet Finder Coronagraph (TPF-C) to operate with a pointing accuracy no better than that of the Hubble Space Telescope. We also provide eighth-order notch filter masks that offer the same robustness to pointing errors combined with more manageable construction tolerances: binary masks and graded masks with moderate optical density requirements.Comment: 21 pages, including 6 figures. Accepted to Ap

NPC1L1 haplotype is associated with inter-individual variation in plasma low-density lipoprotein response to ezetimibe

BACKGROUND: NPC1L1 encodes a putative intestinal sterol transporter which is the likely target for ezetimibe, a new type of lipid-lowering medication. We previously reported rare non-synonymous mutations in NPC1L1 in an individual who had no plasma lipoprotein response to ezetimibe. We next hypothesized that common variants in NPC1L1 would underlie less extreme inter-individual variations in the plasma LDL cholesterol response to ezetimibe. RESULTS: In 101 dyslipidemic subjects, we found that NPC1L1 haplotype was significantly associated with inter-individual variation in the response of plasma LDL cholesterol to treatment with ezetimibe for 12 weeks. Specifically, about one subject in eight lacked the common NPC1L1 haplotype 1735C-25342A-27677T and these subjects had a significantly greater reduction in plasma LDL cholesterol with ezetimibe than subjects with at least one copy of this haplotype (-35.9+4.0 versus -23.6+1.6 percent reduction, P = 0.0054). This was paralleled by a similar non-significant trend of between-haplotype difference in reduction of total cholesterol. CONCLUSION: These preliminary pharmacogenetic results suggest that NPC1L1 variation is associated with inter-individual variation in response to ezetimibe treatment

Taste, Olfactory and Trigeminal Neophobia in Rats with Forebrain Lesions

The present study was designed to examine whether lesions of the insular cortex (IC; Experiment 1), the basolateral amygdala (BLA) or medial amygdala (MeA; Experiment 2) influence the neophobic reactions to orally consumed liquid stimuli. Three different types of stimuli were used: taste (0.5% saccharin), olfactory (0.1% amyl acetate), and trigeminal (0.01 mM capsaicin). Rats with IC, BLA and MeA lesions showed normal responses to the olfactory and trigeminal stimuli. Each type of lesion, however, disrupted the initial occurrence of neophobia to the taste stimulus. The significance of these findings to conditioned taste aversion is discussed

Ba2Si3P6: 1D Nonlinear Optical Material with Thermal Barrier Chains

A novel barium silicon phosphide was synthesized and characterized. Ba2Si3P6 crystallizes in the noncentrosymmetric space group Pna21 (No. 33) and exhibits a unique bonding connectivity in the Si–P polyanion not found in other compounds. The crystal structure is composed of SiP4 tetrahedra connected into one-dimensional double-tetrahedra chains through corner sharing, edge sharing, and covalent P–P bonds. Chains are surrounded by Ba cations to achieve an electron balance. The novel compound exhibits semiconducting properties with a calculated bandgap of 1.6 eV and experimental optical bandgap of 1.88 eV. The complex pseudo-one-dimensional structure manifests itself in the transport and optical properties of Ba2Si3P6, demonstrating ultralow thermal conductivity (0.56 W m–1 K–1 at 300 K), promising second harmonic generation signal (0.9 × AgGaS2), as well as high laser damage threshold (1.6 × AgGaS2, 48.5 MW/cm2) when compared to the benchmark material AgGaS2. Differential scanning calorimetry reveals that Ba2Si3P6 melts congruently at 1373 K, suggesting that large single crystal growth may be possible

Adhesive bonding of copper prepared by laser-interference near the interference structuring limits

Adhesive bonding requires adequate surface preparation for ensuring an appropriate joint quality. The interest in adhesive joining has recently expanded to thermal systems having a large number of joints employed for manufacturing and assembly. This study presents surface topology of copper 110 produced by a laser-interference setup that would theoretically yield a periodicity of 1.7 mm, which is near the 1.6-2 mm structuring limit that was estimated based on thermal diffusion length scale for an 8 ns laser pulse. The results show that although the expected periodic interference structuring was not attained, the melt-induced texturing was affected by the laser-interference profile. Single-lap shear tests are performed with specimen surfaces prepared by traditional abrasion and laser interference structuring methods. Several laser processing parameters, such as the laser spot size, density, number of pulses, and raster speed were studied. Scanning electron microscope and profilometry measurements were used to characterize the processed surface microstructures. Web-like structures, which indicate widespread melting, were shown to be formed at different processing conditions. Based on the surface topologies investigated, two laser raster speeds were selected to make single-lap-joint specimens. Baseline joints were prepared by abrading joining specimens. The shear-lap strength and displacement at maximum load were shown to be higher by 16.8% and 43.8% for the laser-structured specimens than those of the baseline specimens, respectively. Moreover, the load-displacement curves indicate that the laser-structured joints are more ductile than those without laser-structuring. The increase ductility for the laser-structured joints was found to yield an increase in the energy absorbed during shear-lap testing of approximately of 80-90% over those measured for baseline joints. It is another indicator that laser-interference structuring enhanced the bonding performance of single-lap shear joints

Quantum Tunneling of Spin Particles in Periodic Potentials with Asymmetric Twin Barriers

The tunneling effect of a periodic potential with an asymmetric twin barrier per period is calculated using the instanton method. The model is derived from the Hamiltonian of a small ferromagnetic particle in an external magnetic field using the spin-coherent-state path integral. The instantons in two neighbouring barriers differ and lead to different level shifts $\triangle\epsilon_1, \triangle\epsilon_2$. We derive with Bloch theory the energy spectrum which has formally the structure of an energy band. The spectrum depends on both level shifts. The removal of Kramer's degeneracy by an external magnetic field is discussed. In addition we find a new kind of quenching of macroscopic quantum coherence which is irrelevant to Kramer's degeneracy.Comment: 18 pages, LaTex, one figur

Measuring Stellar Radial Velocities with a Dispersed Fixed-Delay Interferometer

We demonstrate the ability to measure precise stellar barycentric radial velocities with the dispersed fixed-delay interferometer technique using the Exoplanet Tracker (ET), an instrument primarily designed for precision differential Doppler velocity measurements using this technique. Our barycentric radial velocities, derived from observations taken at the KPNO 2.1 meter telescope, differ from those of Nidever et al. by 0.047 km/s (rms) when simultaneous iodine calibration is used, and by 0.120 km/s (rms) without simultaneous iodine calibration. Our results effectively show that a Michelson interferometer coupled to a spectrograph allows precise measurements of barycentric radial velocities even at a modest spectral resolution of R ~ 5100. A multi-object version of the ET instrument capable of observing ~500 stars per night is being used at the Sloan 2.5 m telescope at Apache Point Observatory for the Multi-object APO Radial Velocity Exoplanet Large-area Survey (MARVELS), a wide-field radial velocity survey for extrasolar planets around TYCHO-2 stars in the magnitude range 7.6<V<12. In addition to precise differential velocities, this survey will also yield precise barycentric radial velocities for many thousands of stars using the data analysis techniques reported here. Such a large kinematic survey at high velocity precision will be useful in identifying the signature of accretion events in the Milky Way and understanding local stellar kinematics in addition to discovering exoplanets, brown dwarfs and spectroscopic binaries.Comment: 9 pages, 4 figures. Accepted for publication in Ap