Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Session 1A Indigenous Relationships to Colorado Mountains

Mountain climates around the globe are intrinsically linked to indigenous peoples whose livelihood strategies, food systems and cultural identities are intimately connected to the mountains in which they live. Indigenous relationships with mountains are currently being degraded by the impacts of climate change. The methodology used consists of literature review, interviews, GIS layers, and a Story Map to address the relationship between indigenous peoples and mountain climate change. This presentation seeks to consider the impact of climate change on mountainous tribal land in Colorado, discuss Indigenous practices for dealing with climate variability, and share resources on mountain focused climate initiatives