Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma-6

for OVA-challenged mice; = 4 Sham). *, P < 0.02 for WT and ΔdblGATA ± Eos versus PBS groups. (B) Mouse lungs from WT, ΔdblGATA, or ΔdblGATA + eosinophils treated as in , and analyzed by HE or PAS stain. Bars, 50 μm.<p><b>Copyright information:</b></p><p>Taken from "Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma"</p><p></p><p>The Journal of Experimental Medicine 2008;205(6):1285-1292.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2413027.</p><p></p

(A) Immunized ΔdblGATA mice were given CCL11/eotaxin-1 during challenge with OVA

Alternatively, immunized WT C57BL/6 or ΔdblGATA mice were just given CCL11/eotaxin. This was followed by AHR analysis by mechanical ventilation ( = 4, repeated 2 times). *, P < 0.05 for ΔdblGATA + Eot/OVA versus WT or ΔdblGATA + Eot alone. (B) Lungs from immunized and i.n. OVA-challenged WT and ΔdblGATA mice or ΔdblGATA mice delivered eotaxin-1 with OVA, were analyzed for CD4 T cells. Some mice challenged with eotaxin/OVA also received anti-CCL11 blocking antibody i.n. ( = 4 mice/group, repeated 2 times). *, P < 0.05 WT versus ΔdblGATA + OVA. Error bars are ± the SEM.<p><b>Copyright information:</b></p><p>Taken from "Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma"</p><p></p><p>The Journal of Experimental Medicine 2008;205(6):1285-1292.</p><p>Published online 9 Jun 2008</p><p>PMCID:PMC2413027.</p><p></p

Main clinical characteristics of COPD patients switching of Clusters between visit 1 and visit 2.

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Correlation analyses between the 15 differentially regulated proteins and main clinical parameters in COPD patients of the COBRA cohort.

Correlation analyses between the 15 differentially regulated proteins and main clinical parameters in COPD patients of the COBRA cohort.</p

Changes in the serum levels of the significantly-regulated proteins between COPD patients from Cluster 1 and Cluster 2.

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Significant correlations between differentially regulated proteins and the incidence of exacerbations and emphysema in patients with COPD at visit 1.

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Differences in clinical characteristics COPD patients from the MLCC cohort between Cluster 1 and Cluster 2 at inclusion.

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Two COPD patient Clusters show differentially expressed proteins enriched for distinct biological pathways.

(A) Volcano plot showing differentially expressed proteins between Cluster 1 and Cluster 2. X axis corresponds to log2 (fold change) and Y axis corresponds to -log10 (FDR). Yellow indicates proteins with significant downregulation and blue indicates those with significant upregulation (Fold change >1.5 and FDR versus Cluster 1, regrouped in three core functions defined as “Immunity and defense”, “Cell fate, repair and remodeling”, and “Metabolism and mitochondria”.</p

Characteristics of COPD patients of the COBRA cohort.

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Biological classification of the top 90 proteins enriched in Cluster 2 COPD patients.

Biological classification of the top 90 proteins enriched in Cluster 2 COPD patients.</p