Brief summary of literature examining single CRP SNPs with CRP levels, and CHD where available

*<p>SNP 5237 was in high LD with another commonly reported SNP -717A>G (rs2794521).</p

Genotype frequency for CRP polymorphisms among cases and controls in Nurses' Health Study (Women) and Health Professionals Follow-up Study (Men)

*<p>P, chi-square, or Fisher's exact test for cells less than 20.</p

Baseline characteristics of participants with incident CHD (cases) and matched* controls among women (Nurses' Health Study) and men (Health Professionals Follow-up Study)^†

*<p>Matched on age, smoking status, date of blood drawing, and fasting status (women only)</p>†<p>Values are least square mean ± standard error for continuous variables and proportions for categorical variables, except for CRP, which is shown as log-transformed geometric mean and 95% confidence interval</p>‡<p>P for difference between cases and controls by matching factor-adjusted t-Test for rows with means, and by Chi-Square Test for rows with proportions</p>§<p>Race unknown in 10 cases and 21 controls (HPFS); 18 cases and 16 controls (NHS)</p

Association of CRP SNPs with risk of coronary heart disease, and with plasma CRP levels among women and men

*<p>Conditional logistic regression under the additive genetic model</p>†<p>Matching factor-adjusted, log-transformed, multiplicative change per copy of the allele among controls</p>‡<p>P for change in CRP levels</p

Common CRP haplotypes, risk of CHD, and relative effects of haplotypes on plasma CRP levels

*<p>Cutoff set as ≥5.0%, based on 744 women and 781 men.</p>†<p>Haplotype-specific ORs (multiplicative increase in odds per copy of haplotype) using unconditional logistic regression, adjusted for matching factors</p>‡<p>Log-transformed CRP adjusted for matching factors</p>§<p>All other haplotypes</p>¥<p>Globally-adjusted likelihood ratio test</p

Pairwise linkage disequilibrium (D') and correlation coefficients (r²) between CRP polymorphisms and control women and men

<p>Pairwise linkage disequilibrium (D') and correlation coefficients (r²) between CRP polymorphisms and control women and men</p

Mean (±SD) numbers of heterozygous loci among CHD cases and controls and odds ratios (95% confidence interval) for CHD associated with heterozygous loci.

<p>Odds ratios adjusted for age, smoking, and population eigenvectors.</p><p>Mean (±SD) numbers of heterozygous loci among CHD cases and controls and odds ratios (95% confidence interval) for CHD associated with heterozygous loci.</p

Association of CHD risk factors with overall heterozygous loci, loci within genes, and nonsynonymous SNPs.

<p>All estimates adjusted for age, smoking, population eigenvectors, and case-control status.</p><p>Association of CHD risk factors with overall heterozygous loci, loci within genes, and nonsynonymous SNPs.</p