10 research outputs found

    Diagnostic algorithm to manage patients with autosomal dominant polycystic kidney disease (ADPKD) presenting with suspected acute cyst complication.

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    <p>*, On the basis of the conventional management (including blood and urine analyses and abdomen imaging) of any patient with febrile abdominal pain in emergency conditions (33).</p

    Score plots from OPLS-DA applied to <sup>1</sup>H-NMR spectra of mouse urine samples following renal ischemia/reperfusion or sham surgery.

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    <p>The upper panels represent the score plots of OPLS-DA from <sup>1</sup>H-NMR metabolomic analysis using mouse urine samples collected after 6-hour (left), 24-hour (middle) and 48-hour (right) reperfusion following renal ischemia (black dots) or sham surgery (grey dots). The lower tables correspondingly list the metabolites whose urinary abundance is significantly increased or decreased after renal ischemia/reperfusion (I/R) in comparison to sham surgery.</p

    Score plot from OPLS-DA applied to <sup>1</sup>H-NMR spectra of mouse kidney lysates following renal ischemia/reperfusion or sham surgery.

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    <p>The upper panels represent the score plots of OPLS-DA from <sup>1</sup>H-NMR metabolomic analysis using mouse kidney lysates collected after 6-hour (left), 24-hour (middle) and 48-hour (right) reperfusion following renal ischemia (black dots) or sham surgery (grey dots). The lower tables correspondingly list the metabolites whose abundance in renal parenchyma is significantly increased or decreased after renal ischemia/reperfusion (I/R) in comparison to sham surgery.</p

    Receiver operating characteristic (ROC) curves of <sup>1</sup>H-NMR metabolomics of mouse kidney samples following renal ischemia/reperfusion or sham surgery.

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    <p>Multivariate ROC curves were drawn using <sup>1</sup>H-NMR metabolomic spectral data from mouse kidney samples collected after 6-hour (left), 24-hour (middle) and 48-hour (right) reperfusion following renal ischemia.</p

    Receiver operating characteristic (ROC) curves of <sup>1</sup>H-NMR metabolomics of mouse urine samples following renal ischemia/reperfusion or sham surgery.

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    <p>Multivariate ROC curves were drawn using <sup>1</sup>H-NMR metabolomic spectral data from mouse urine samples collected after 6-hour (left), 24-hour (middle) and 48-hour (right) reperfusion following renal ischemia.</p

    Nuclear Magnetic Resonance Metabolomic Profiling of Mouse Kidney, Urine and Serum Following Renal Ischemia/Reperfusion Injury - Fig 1

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    <p><b>Serum levels of creatinine (A) and blood urea (B) in mice following renal ischemia/reperfusion or sham surgery</b>. Unpaired Student t-test between groups of renal ischemia/reperfusion (I/R) and sham surgery showed statistically significant differences (*, <i>p<0</i>.<i>05; **</i>, <i>p<0</i>.<i>01; ***</i>, <i>p<0</i>.<i>001</i>) for both serum creatinine and urea levels at 6h and 24h <i>post</i> reperfusion.</p
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