Clinical characteristics of osteosarcoma patients (<i>N</i> = 102).

<p>Clinical characteristics of osteosarcoma patients (<i>N</i> = 102).</p

Kaplan-Meier survival curves for osteosarcoma patients according to genotype for (A) rs4148416 in <i>ABCC3</i> (X² = 21.4, <i>p-value</i> = 3.8×10⁻⁶); (B) rs4148737 in <i>ABCB1</i> (X² = 18.4, <i>p-value</i> = 1.0×10⁻⁴); and (C) rs1128503 or rs10276036 in <i>ABCB1</i> (X² = 20.9, <i>p-value</i> = 2.9×10⁻⁵<i>).</i>

<p>Kaplan-Meier survival curves for osteosarcoma patients according to genotype for (A) rs4148416 in <i>ABCC3</i> (X² = 21.4, <i>p-value</i> = 3.8×10⁻⁶); (B) rs4148737 in <i>ABCB1</i> (X² = 18.4, <i>p-value</i> = 1.0×10⁻⁴); and (C) rs1128503 or rs10276036 in <i>ABCB1</i> (X² = 20.9, <i>p-value</i> = 2.9×10⁻⁵<i>).</i></p

Genes and polymorphisms associated with overall survival (OS) and event free survival (EFS).

<p>*HR: Hazard Ratio.</p><p>**Analysis adjusted for metastasis at diagnosis.</p

Association of rs12662670 with breast cancer in European ER

<p>−<b>*versus ER+**cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p

Association of rs2046210 with breast cancer in European ER

<p>−<b>*versus ER+*cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p

Association of rs2046210 and rs12662670 with breast cancer.

<p>Results are presented overall and separately for Europeans and Asians. Pooled analyses adjusted for study only as well as adjusted for rs12662670 or rs2046210, respectively, in addition to study were performed.</p>a<p>P-value derived from the log-additive model.</p>b<p>Odds ratio per minor allele (A allele for rs2046210, G allele for rs12662670).</p>c<p>Odds ratio relative to the major allele homozygous (GT) genotype.</p

Linkage disequilibrium blocks in the <i>ESR1</i> region.

<p>Five SNPs tagged (at r2>0.9) by rs12662670 and three by rs2046210 are marked by arrows (dark and light grey respectively); rs12662670 and rs2046210 are marked by stars; rs3757318 and rs9397435 are marked by points; blocks were generated using data from the 1000 Genomes Project and HapMap; blocks include all single nucleotide polymorphisms with a minor allele frequency >0.05. The directions of translation of <i>ESR1</i> and <i>C6orf97</i> are marked and other genes in the locus are listed.</p

Association of rs2046210 with breast cancer in Asian ER

<p>−<b>*versus ER+**cases and controls.</b> *Estrogen receptor negative; **Estrogen receptor positive.</p

Association of rs12662670 with breast cancer in Europeans versus Asians.

<p>Association of rs12662670 with breast cancer in Europeans versus Asians.</p

Association of haplotypes composed of rs2046210 and rs12662670 with breast cancer.

<p>Results are presented overall and separately for Europeans and Asians. Pooled analyses adjusted for study were performed.</p>a<p>Odds ratio per haplotype compared to the reference haplotype (i.e., the most frequent haplotype).</p>b<p>P-value derived from the log-additive model.</p>c<p>Minor allele.</p>d<p>Reference haplotype.</p