Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia-2

<p><b>Copyright information:</b></p><p>Taken from "Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia"</p><p>BMC Neuroscience 2004;5():55-55.</p><p>Published online 8 Dec 2004</p><p>PMCID:PMC544856.</p><p>Copyright © 2004 Petzelt et al; licensee BioMed Central Ltd.</p>l survival after two-hour incubation. No effect was observed on PC-12 cells maintained under normal conditions or in xenon, however, for cells kept in nitrogen, a concentration-dependent decrease of cellular damage was found, indicating that the D1-receptor was involved to convey the cellular damage. (n = 4; **P < 0.01 and *P < 0.05 with respect to untreated controls). B. Effect of various concentrations of the D2-receptor antagonist sulpiride on cell survival after two-hour incubation. No protective effect of sulpiride was found for cells incubated in nitrogen, even a slight increase of cellular damage was seen with increasing concentrations of sulpiride

Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia-5

<p><b>Copyright information:</b></p><p>Taken from "Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia"</p><p>BMC Neuroscience 2004;5():55-55.</p><p>Published online 8 Dec 2004</p><p>PMCID:PMC544856.</p><p>Copyright © 2004 Petzelt et al; licensee BioMed Central Ltd.</p>s, in N, or in xenon. Mesencephalic cells containing dopaminergic neurons were exposed on day 14 after preparation for two hours either to normal atmosphere, or xenon or nitrogen. Dopamine was not released from cells maintained under normal conditions or in xenon whereas a significant amount of dopamine was liberated from cells maintained in nitrogen. B. Cellular damage in mesencephalic dopaminergic cells after two-hour incubation. If cells were kept in normal air, or in xenon, only a small amount of LDH was released. Much higher cellular damage was found when cells were incubated in nitrogen. (n = 4; **P < 0.01)

Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia-0

<p><b>Copyright information:</b></p><p>Taken from "Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia"</p><p>BMC Neuroscience 2004;5():55-55.</p><p>Published online 8 Dec 2004</p><p>PMCID:PMC544856.</p><p>Copyright © 2004 Petzelt et al; licensee BioMed Central Ltd.</p>N, or in xenon. Whereas almost no dopamine was released from control cells during the two-hour period, a strong increase of extracellular dopamine was found when cells were kept in N. When cells were maintained in a xenon-atmosphere, no dopamine release occurred, there was virtually no difference compared to controls. B. Assessment of cellular damage in PC-12 cells after two-hour incubation. If cells were kept in normal air, or in xenon, only a small amount of LDH was released. Much higher cellular damage was found when cells were incubated in N. (n = 5; **P < 0.01 with respect to untreated controls)