Correlation between albumin transcapillary escape rate (TER) and inflammatory parameters 2 days after major pancreatic surgery, n = 10.

<p>A: TER versus C-reactive protein, B: TER versus white blood cell count (WBC).</p

Physiological data before and 2 days after major pancreatic surgery, n = 10.

<p>^a Systemic inflammatory response syndrome parameter.</p><p>Values are presented as mean (95% CI) or median (range), and differences analysed by ¹paired t-test or ²Wilcoxon’s matched pairs test, respectively.</p

CONSORT diagram of patients.

<p>Logistic reasons for exclusion: Limits in research staff, more than one simultaneous pancreatic surgical procedure, and no available radioiodine isotope</p

Albumin kinetic parameters in surgical patients assessed by flooding technique with d5-phenylalanin and dilution of iodinated human serum albumin, n = 10.

<p>A: Fractional synthesis rate (FSR), B: Absolute synthesis rate (ASR), Panel C: Transcapillary escape rate (TER). Measurements are performed immediately before (open circles) and two days after major pancreatic surgery (closed circles).</p

Patient characteristics.

<p>Values are presented as median (range) or mean ± sd. ASA, American Society of Anesthesiologists.</p

Albumin kinetic parameters.

<p>Values presented as mean (95% confidence interval), before and 2 days after major pancreatic surgery, n = 10. Plasma volume and transcapillary escape rate were calculated from the slope 0–60 min after isotope injection. Blood volume was calculated from plasma volume and hematocrit assuming an F-ratio of 0.91.</p

Flow chart of blood sampling, identical between day 0 and day 2.

<p>Black arrows: sampling of ¹²⁵I-human serum albumin for determination of plasma volume and transcapillary escape rate. Gray arrows: sampling of l-[²H₅] phenylalanine-albumin and l-[²H₅] phenylalanine (precursor pool) for determination of albumin fractional synthesis rate.</p

Additional file 3: Text S2. of Leakage of albumin in major abdominal surgery

Simulations over five possible confounders in the albumin mass balance calculations. Text, references and figure legends. (DOCX 25 kb

Additional file 2: Figure S1. of Leakage of albumin in major abdominal surgery

Temporal pattern of P-albumin, plasma dilution, and cumulative perioperative albumin shift. (EPS 66 kb

Additional file 1: Text S1. of Leakage of albumin in major abdominal surgery

A case report of albumin infusion compared to starch. (DOCX 13 kb