1 research outputs found
Scale-Up of an Enantioselective Overman Rearrangement for an Asymmetric Synthesis of a Glycine Transporter 1 Inhibitor
An enantioselective Overman 3,3-sigmatropic rearrangement
on a quinuclidine skeleton was developed for the pilot-plant synthesis
of a glycine transporter 1 inhibitor. The first stereocenter was produced
by a Ru-catalyzed asymmetric transfer hydrogenation process followed
by chirality transfer using the Overman rearrangement. The second
stereocenter was generated by a diastereoselective hydrogenation reaction