3 research outputs found
Versatile Ring-Opening Copolymerization and Postprinting Functionalization of Lactone and Poly(propylene fumarate) Block Copolymers: Resorbable Building Blocks for Additive Manufacturing
Additive
manufacturing has the potential to change medicine, but
clinical applications are limited by a lack of resorbable, printable
materials. Herein, we report the first synthesis of polylactone and
polyÂ(propylene fumarate) (PPF) block copolymers with well-defined
molecular masses and molecular mass distributions using sequential,
ring-opening polymerization and ring-opening copolymerization methods.
These new copolymers represent a diverse platform of resorbable printable
materials. Furthermore, these polymers open a previously unexplored
range of accessible properties among stereolithographically printable
materials, which we demonstrate by printing a polymer with a molecular
mass nearly 4 times that of the largest PPF homopolymer previously
printed. To further demonstrate the potential of these materials in
regenerative medicine, we report the postprinting “click”
functionalization of the material using a copper-mediated azide–alkyne
cycloaddition
Dual Catalysis for Selective Ring-Opening Polymerization of Lactones: Evolution toward Simplicity
Much
work has been directed to the design of complex single-site
catalysts for ring-opening polymerization (ROP) to enhance both activity
and selectivity. More simply, however, cooperative effects between
Lewis acids and organocatalytic nucleophiles/Lewis bases provide a
powerful alternative. In this study we demonstrate that the combination
of <i>N</i>-heterocyclic carbenes, 1,8-diazabicycloundec-7-ene
(DBU) and 4-dimethylaminopyridine (DMAP) with simple Lewis acids enables
the ROP of the macrolactone pentadecalactone in a rapid and efficient
manner. Remarkably, regardless of the nature of the nucleophile, the
order of activity was observed to be MgX<sub>2</sub> ≫ YCl<sub>3</sub> ≫ AlCl<sub>3</sub> and MgI<sub>2</sub> > MgBr<sub>2</sub> > MgCl<sub>2</sub> in every case. The minimal influence
of
the organobase on polymerization activity allows for the use of simple
and inexpensive precursors. Furthermore, extension of the study to
other cyclic (di)Âester monomers reveals the choice of Lewis acid to
lead to monomer selective ROP activity and hence control over copolymer
composition by choice of Lewis acid. This approach could lead to the
realization of complex polymer structures with tunable physical properties
from simple catalyst combinations
Polymers from macrolactones: from pheromones to functional materials.
Recent advances in the ring-opening polymerization (ROP) of macrolactones (MLs) have afforded access to novel, potentially degradable polymeric materials featuring long aliphatic chains. These developments extend the synthetic robustness and versatility of ROP to a greater range of interesting monomers, many of which can be derived from sustainable or renewable feedstocks, to access polymeric materials boasting a diversity of properties and potential applications. This review discusses current strategies to catalyse the ROP of MLs, comparing and contrasting them with those known for the ROP of small and medium sized lactones, and highlights recent developments in the preparation, functionalization, and application of materials featuring poly(macrolactone)s (PMLs)