2 research outputs found
Biodegradable Elastomers and Silicon Nanomembranes/Nanoribbons for Stretchable, Transient Electronics, and Biosensors
Transient
electronics represents an emerging class of technology that exploits
materials and/or device constructs that are capable of physically
disappearing or disintegrating in a controlled manner at programmed
rates or times. Inorganic semiconductor nanomaterials such as silicon
nanomembranes/nanoribbons provide attractive choices for active elements
in transistors, diodes and other essential components of overall systems
that dissolve completely by hydrolysis in biofluids or groundwater.
We describe here materials, mechanics, and design layouts to achieve
this type of technology in stretchable configurations with biodegradable
elastomers for substrate/encapsulation layers. Experimental and theoretical
results illuminate the mechanical properties under large strain deformation.
Circuit characterization of complementary metal-oxide-semiconductor
inverters and individual transistors under various levels of applied
loads validates the design strategies. Examples of biosensors demonstrate
possibilities for stretchable, transient devices in biomedical applications
Stretchable, Implantable, Nanostructured Flow-Diverter System for Quantification of Intra-aneurysmal Hemodynamics
Random
weakening of an intracranial blood vessel results in abnormal
blood flow into an aneurysmal sac. Recent advancements show that an
implantable flow diverter, integrated with a medical stent, enables
a highly effective treatment of cerebral aneurysms by guiding blood
flow into the normal vessel path. None of such treatment systems,
however, offers post-treatment monitoring to assess the progress of
sac occlusion. Therefore, physicians rely heavily on either angiography
or magnetic resonance imaging. Both methods require a dedicated facility
with sophisticated equipment settings and time-consuming, cumbersome
procedures. In this paper, we introduce an implantable, stretchable,
nanostructured flow-sensor system for quantification of intra-aneurysmal
hemodynamics. The open-mesh membrane device is capable of effective
implantation in complex neurovascular vessels with extreme stretchability
(500% radial stretching) and bendability (180° with 0.75 mm radius
of curvature) for monitoring of the treatment progress. A collection
of quantitative mechanics, fluid dynamics, and experimental studies
establish the fundamental aspects of design criteria for a highly
compliant, implantable device. Hemocompatibility study using fresh
ovine blood captures the device feasibility for long-term insertion
in a blood vessel, showing less platelet deposition compared to that
in existing implantable materials. <i>In vitro</i> demonstrations
of three types of flow sensors show quantification of intra-aneurysmal
blood flow in a pig aorta and the capability of observation of aneurysm
treatment with a great sensitivity (detection limit as small as 0.032
m/s). Overall, this work describes a mechanically soft flow-diverter
system that offers an effective treatment of aneurysms with an active
monitoring of intra-aneurysmal hemodynamics