7 research outputs found

    Emergence in Western African Countries of MDR-TB, Focus on Côte d’Ivoire

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    Tuberculosis (TB) is responsible for a high mortality rate (2.5%) worldwide, mainly in developing countries with a high prevalence of human immunodeficiency virus (HIV). The emergence of multiresistant strains of TB poses an extreme risk for TB outbreaks and highlights the need for global TB control strategies. Among Western African countries, Côte d’Ivoire (CI) represents a specific example of a country with great potential to prevent TB. Specifically, CI has a promising healthcare system for monitoring diseases, including vaccination programs. However, military and political conflict in CI favors the spread of infectious diseases, TB being among the most devastating. Compilation of the studies identifying common causes of TB would be extremely beneficial for the development of treatment and prevention strategies. Therefore, the purpose of this comprehensive review is to evaluate the epidemiology of TB in CI, describe the factors involved in pathogenesis, and suggest simple and applicable prevention strategies

    Spoligotypes identified by a SIT number in the SITVIT database.

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    1<p>SIT: Shared International Type.</p>2<p>The black and white boxes indicate the presence and absence, respectively, of the specific spacer at positions 1–43 in the DR locus.</p>3<p>Clade designations according to SpolDB4 database.</p

    Dendrogram generated using MIRU-VNTR profiles of 74 strains identified as SIT 53 by spoligotyping.

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    <p>Samples CIV000067, CIV000077 and CIV000093 are characterized by the presence of double alleles for Mtub30 (4+2), Mtub21 (4+3) and Miru40 (5+2) respectively.</p

    Spoligotypes of orphan strains and clusters not identified in the SITVIT database.

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    1<p>DNA identification in the sample database.</p>2<p>The black and white boxes indicate the presence and absence, respectively, of the specific spacer at positions 1–43 in the DR locus.</p
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