997 research outputs found
Mindfulness in the focus of the neurosciences - The contribution of neuroimaging to the understanding of mindfulness.
Background
Mindfulness affects human levels of experience by facilitating the immediate and impartial perception of phenomena, including sensory stimulation, emotions, and thoughts. Mindfulness is now a focus of neuroimaging, since technical and methodological developments in magnetic resonance imaging have made it possible to observe subjects performing mindfulness tasks.
Objective
We set out to describe the association between mental processes and characteristics of mindfulness, including their specific cerebral patterns, as shown in structural and functional neuroimaging studies.
Methods
We searched the MEDLINE databank of references and abstracts on life sciences and biomedical topics via PubMed using the keywords: "mindfulness," "focused attention (FA)," "open monitoring (OM)," "mind wandering," "emotional regulation," "magnetic resonance imaging (MRI)" and "default mode network (DMN)." This review extracted phenomenological experiences across populations with varying degrees of mindfulness training and correlated these experiences with structural and functional neuroimaging patterns. Our goal was to describe how mindful behavior was processed by the constituents of the default mode network during specific tasks.
Results and conclusions
Depending on the research paradigm employed to explore mindfulness, investigations of function that used fMRI exhibited distinct activation patterns and functional connectivities. Basic to mindfulness is a long-term process of learning to use meditation techniques. Meditators progress from voluntary control of emotions and subjective preferences to emotional regulation and impartial awareness of phenomena. As their ability to monitor perception and behavior, a metacognitive skill, improves, mindfulness increases self-specifying thoughts governed by the experiential phenomenological self and reduces self-relational thoughts of the narrative self. The degree of mindfulness (ratio of self-specifying to self-relational thoughts) may affect other mental processes, e.g., awareness, working memory, mind wandering and belief formation. Mindfulness prevents habituation and the constant assumptions associated with mindlessness. Self-specifying thinking during mindfulness and self-relational thinking in the narrative self relies on the default mode network. The main constituents of this network are the dorsal and medial prefrontal cortex, and posterior cingulate cortex. These midline structures are antagonistic to self-specifying and self-relational processes, since the predominant process determines their differential involvement. Functional and brain volume changes indicate brain plasticity, mediated by mental training over the long-term
A rigorous analysis of high order electromagnetic invisibility cloaks
There is currently a great deal of interest in the invisibility cloaks
recently proposed by Pendry et al. that are based in the transformation
approach. They obtained their results using first order transformations. In
recent papers Hendi et al. and Cai et al. considered invisibility cloaks with
high order transformations. In this paper we study high order electromagnetic
invisibility cloaks in transformation media obtained by high order
transformations from general anisotropic media. We consider the case where
there is a finite number of spherical cloaks located in different points in
space. We prove that for any incident plane wave, at any frequency, the
scattered wave is identically zero. We also consider the scattering of finite
energy wave packets. We prove that the scattering matrix is the identity, i.e.,
that for any incoming wave packet the outgoing wave packet is the same as the
incoming one. This proves that the invisibility cloaks can not be detected in
any scattering experiment with electromagnetic waves in high order
transformation media, and in particular in the first order transformation media
of Pendry et al. We also prove that the high order invisibility cloaks, as well
as the first order ones, cloak passive and active devices. The cloaked objects
completely decouple from the exterior. Actually, the cloaking outside is
independent of what is inside the cloaked objects. The electromagnetic waves
inside the cloaked objects can not leave the concealed regions and viceversa,
the electromagnetic waves outside the cloaked objects can not go inside the
concealed regions. As we prove our results for media that are obtained by
transformation from general anisotropic materials, we prove that it is possible
to cloak objects inside general crystals.Comment: The final version is now published in Journal of Physics A:
Mathematical and Theoretical, vol 41 (2008) 065207 (21 pp). Included in
IOP-Selec
Nonlocal ultrafast demagnetization dynamics of Co/Pt multilayers by optical field enhancement
The influence on ultrafast demagnetization dynamics of metallic nano-structured gratings deposited on thin films of magnetic Co/Pt multilayers is investigated by the time-resolved optical Kerr effect. Depending on the polarization of the pump pulse, a pronounced enhancement of the demagnetization amplitude is found. Calculation of the inhomogeneous optical field distribution due to plasmon interaction and time-dependent solutions of the coupled electron, lattice, and spin temperatures in two dimensions show good agreement with the experimental data, as well as giving evidence of non-local demagnetization dynamics due to electron diffusion.BMBF, 05K10KTB, Verbundprojekt: FSP 301 - FLASH: Nanoskopische Systeme. Teilprojekt 1.1: Universelle Experimentierkammer für Streuexperimente mit kohärenten Femtosekunden-Röntgenpulsen Multi Purpose Coherent Scattering Chamber for FLASH and XFEL 'MPscatt
Inverse Scattering at a Fixed Quasi-Energy for Potentials Periodic in Time
We prove that the scattering matrix at a fixed quasi--energy determines
uniquely a time--periodic potential that decays exponentially at infinity. We
consider potentials that for each fixed time belong to in space. The
exponent 3/2 is critical for the singularities of the potential in space. For
this singular class of potentials the result is new even in the
time--independent case, where it was only known for bounded exponentially
decreasing potentials.Comment: In this revised version I give a more detailed motivation of the
class of potentials that I consider and I have corrected some typo
Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Design and performance of personal cooling garments based on three-layer laminates
Personal cooling systems are mainly based on cold air or liquids circulating through a tubing system. They are weighty, bulky and depend on an external power source. In contrast, the laminate-based technology presented here offers new flexible and light weight cooling garments integrated into textiles. It is based on a three-layer composite assembled from two waterproof, but water vapor permeable membranes and a hydrophilic fabric in between. Water absorbed in the fabric will be evaporated by the body temperature resulting in cooling energy. The laminate's high adaptiveness makes it possible to produce cooling garments even for difficult anatomic topologies. The determined cooling energy of the laminate depends mainly on the environmental conditions (temperature, relative humidity, wind): heat flux at standard climatic conditions (20°C, 65% R.H., wind 5km/h) has measured 423.2±52.6W/m2, water vapor transmission resistance, R et, 10.83±0.38m2Pa/W and thermal resistance, R ct, 0.010±0.002m2K/W. Thermal conductivity, k, changed from 0.048±0.003 (dry) to 0.244±0.018W/mK (water added). The maximum fall in skin temperature, ∆T max, under the laminate was 5.7±1.2°C, taken from a 12 subject study with a thigh cooling garment during treadmill walking (23°C, 50% R.H., no wind) and a significant linear correlation (R=0.85, P=0.01) between body mass index and time to reach 67% of ∆T max could be determine
Mechanically adaptive nanocomposites for neural interfacing
The recording of neural signals with microelectrodes that are implanted into the cortex of the brain is potentially useful for a range of clinical applications. However, the widespread use of such neural interfaces has so far been stifled because existing intracortical electrode systems rarely allow for consistent long-term recording of neural activity. This limitation is usually attributed to scar formation and neuron death near the surface of the implanted electrode. It has been proposed that the mechanical property mismatch between existing electrode materials and the brain tissue is a significant contributor to these events. To alleviate this problem, we utilized the architecture of the sea cucumber dermis as a blueprint to engineer a new class of mechanically adaptive materials as substrates for "smart” intracortical electrodes. We demonstrated that these originally rigid polymer nanocomposites soften considerably upon exposure to emulated physiological and in vivo conditions. The adaptive nature of these bioinspired materials makes them useful as a basis for electrodes that are sufficiently stiff to be easily implanted and subsequently soften to better match the stiffness of the brain. Initial histological evaluations suggest that mechanically adaptive neural prosthetics can more rapidly stabilize neural cell populations at the device interface than rigid systems, which bodes well for improving the functionality of intracortical device
Neural networks engaged in tactile object manipulation: patterns of expression among healthy individuals
<p>Abstract</p> <p>Background</p> <p>Somatosensory object discrimination has been shown to involve widespread cortical and subcortical structures in both cerebral hemispheres. In this study we aimed to identify the networks involved in tactile object manipulation by principal component analysis (PCA) of individual subjects. We expected to find more than one network.</p> <p>Methods</p> <p>Seven healthy right-handed male volunteers (aged 22 to 44 yrs) manipulated with their right hand aluminium spheres during 5 s with a repetition frequency of 0.5-0.7 Hz. The correlation coefficients between the principal component temporal expression coefficients and the hemodynamic response modelled by SPM (ecc) determined the task-related components. To establish reproducibility within subjects and similarity of functional connectivity patterns among subjects, regional correlation coefficients (rcc) were computed between task-related component image volumes. By hierarchically categorizing, selecting and averaging the task-related component image volumes across subjects according to the rccs, mean component images (MCIs) were derived describing neural networks associated with tactile object manipulation.</p> <p>Results</p> <p>Two independent mean component images emerged. Each included the primary sensorimotor cortex contralateral to the manipulating hand. The region extended to the premotor cortex in MCI 1, whereas it was restricted to the hand area of the primary sensorimotor cortex in MCI 2. MCI 1 showed bilateral involvement of the paralimbic anterior cingulate cortex (ACC), whereas MCI 2 implicated the midline thalamic nuclei and two areas of the rostral dorsal pons.</p> <p>Conclusions</p> <p>Two distinct networks participate in tactile object manipulation as revealed by the intra- and interindividual comparison of individual scans. Both were employed by most subjects, suggesting that both are involved in normal somatosensory object discrimination.</p
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