Identifying progressive imaging genetic patterns via multi-task sparse canonical correlation analysis: a longitudinal study of the ADNI cohort

Motivation Identifying the genetic basis of the brain structure, function and disorder by using the imaging quantitative traits (QTs) as endophenotypes is an important task in brain science. Brain QTs often change over time while the disorder progresses and thus understanding how the genetic factors play roles on the progressive brain QT changes is of great importance and meaning. Most existing imaging genetics methods only analyze the baseline neuroimaging data, and thus those longitudinal imaging data across multiple time points containing important disease progression information are omitted. Results We propose a novel temporal imaging genetic model which performs the multi-task sparse canonical correlation analysis (T-MTSCCA). Our model uses longitudinal neuroimaging data to uncover that how single nucleotide polymorphisms (SNPs) play roles on affecting brain QTs over the time. Incorporating the relationship of the longitudinal imaging data and that within SNPs, T-MTSCCA could identify a trajectory of progressive imaging genetic patterns over the time. We propose an efficient algorithm to solve the problem and show its convergence. We evaluate T-MTSCCA on 408 subjects from the Alzheimer’s Disease Neuroimaging Initiative database with longitudinal magnetic resonance imaging data and genetic data available. The experimental results show that T-MTSCCA performs either better than or equally to the state-of-the-art methods. In particular, T-MTSCCA could identify higher canonical correlation coefficients and capture clearer canonical weight patterns. This suggests that T-MTSCCA identifies time-consistent and time-dependent SNPs and imaging QTs, which further help understand the genetic basis of the brain QT changes over the time during the disease progression. Availability and implementation The software and simulation data are publicly available at https://github.com/dulei323/TMTSCCA. Supplementary information Supplementary data are available at Bioinformatics online

Elimination of negative differential conductance in an asymmetric molecular transistor by an ac-voltage

We analyze resonant tunneling subject to a non-adiabatic time-dependent bias-voltage through an asymmetric single molecular quantum dot with coupling between the electronic and vibrational degrees of freedom using a {\em Tien-Gordon-type} rate equation. Our results clearly exhibit the appearance of photon-assisted satellites in the current-voltage characteristics and the elimination of hot-phonon-induced negative differential conductance with increasing ac driving amplitude for an asymmetric system. This can be ascribed to an {\em ac-induced suppression} of unequilibrated (hot) phonons in an asymmetric system.Comment: Accepted by Appl. Phys. Let

Finite-frequency current (shot) noise in coherent resonant tunneling through a coupled-quantum-dot interferometer

We examine the shot noise spectrum properties of coherent resonant tunneling in coupled quantum dots in both series and parallel arrangements by means of quantum rate equations and MacDonald's formula. Our results show that, for a series-CQD with a relatively high dot-dot hopping $\Omega$, $\Omega/\Gamma\gtrsim 1$ ($\Gamma$ denotes the dot-lead tunnel-coupling strength), the noise spectrum exhibits a dip at the Rabi frequency, $2\Omega$, in the case of noninteracting electrons, but the dip is supplanted by a peak in the case of strong Coulomb repulsion; furthermore, it becomes a dip again for a completely symmetric parallel-CQD by tuning enclosed magnetic-flux.Comment: 8 pages, 5 figure

Inverse Spin Hall Effect by Spin Injection

Motivated by a recent experiment[Nature {\bf 442}, 176 (2006)], we present a quantitative microscopic theory to investigate the inverse spin-Hall effect with spin injection into aluminum considering both intrinsic and extrinsic spin-orbit couplings using the orthogonalized-plane-wave method. Our theoretical results are in good agreement with the experimental data. It is also clear that the magnitude of the anomalous Hall resistivity is mainly due to contributions from extrinsic skew scattering, while its spatial variation is determined by the intrinsic spin-orbit coupling.Comment: 5 pages, 3 figure