1,962 research outputs found

    Efficiency Costs of Meeting Industry-Distributional Constraints under Environmental Permits and Taxes

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    A politically realistic approach to environmental policy seems to require avoiding significant profit-losses in major pollution-related industries. The government can avoid such losses by freely allocating some emissions permits or by exempting some inframarginal emissions from a pollution tax. However, preventing profit-losses in this way involves an efficiency cost because it compels the government to forego especially efficient sources of revenue and to rely more heavily on ordinary, distortionary taxes. Using analytically and numerically solved equilibrium models, we analyze these efficiency costs. We find that when the required amount of abatement is small, the efficiency cost implied by the profits-constraint dwarfs the other efficiency costs of pollution-control. When the abatement requirement becomes more extensive, the cost of this constraint diminishes relative to the other efficiency costs. We also calculate and analyze the determinants of the gross compensation ratio' the share of pollution permits that must be freely allocated to prevent profit-losses in the targeted industries. Numerical simulations of sulfur dioxide pollution-control suggest that the Bush Administration's Clear Skies Initiative would exceed this ratio, freely allocating more permits than necessary to preserve profits.

    TELLUS: A combined surface temperature, soil moisture and evaporation mapping approach

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    How to calculate the dose of chemotherapy

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    Body surface area-dosing does not account for the complex processes of cytotoxic drug elimination. This leads to an unpredictable variation in effect. Overdosing is easily recognised but it is possible that unrecognised underdosing is more common and may occur in 30% or more of patients receiving standard regimen. Those patients who are inadvertently underdosed are at risk of a significantly reduced anticancer effect. Using published data, it can be calculated that there is an almost 20% relative reduction in survival for women receiving adjuvant chemotherapy for breast cancer as a result of unrecognised underdosing. Similarly, the cure rate of cisplatin-based chemotherapy for advanced testicular cancer may be reduced by as much as 10%. The inaccuracy of body surface area-dosing is more than an inconvenience and it is important that methods for more accurate dose calculation are determined, based on the known drug elimination processes for cytotoxic chemotherapy. Twelve rules for dose calculation of chemotherapy are given that can be used as a guideline until better dose-calculation methods become available. Consideration should be given to using fixed dose guidelines independent of body surface area and based on drug elimination capability, both as a starting dose and for dose adjustment, which may have accuracy, safety and financial advantages
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