Collaborative Network Tools for the Architectural Analysis in Conservation Research

Development of net-based tools initiate a new architecture-computer science junction, offering a possibility to investigate distant exchange and updating of research work on architectural artefacts. Tools such as CAD platforms, rendering software and DBMS are integrated to the every day work of more and more architects and conservationists. Computer tools, which have been introduced in the process of analysing architecture as drawing and data management platforms, now bring to the fore a deeper change: distant analysis. The development of web technologies and the object oriented approach to knowledge representation give us an opportunity of research in the fields of collaborative work on architectural data models. The research presented in this paper focuses on a first set of network operative tools for a co-operation program aimed at developing web-enabled architectural data models referring to the evolution of Cracow's Old Town Hall

Structure of gamma conglutin insight into the quaternary structure of 7S basic globulins from legumes

γ-Conglutin from lupin seeds is an unusual 7S basic globulin protein. It is capable of reducing glycaemia in mammals, but the structural basis of this activity is not known. γ-Conglutin shares a high level of structural homology with glycoside hydrolase inhibitor proteins, although it lacks any kind of inhibitory activity against plant cell-wall degradation enzymes. In addition, γ-conglutin displays a less pronounced structural similarity to pepsin-like aspartic proteases, but it is proteolytically dysfunctional. Only one structural study of a legume 7S basic globulin, that isolated from soybean, has been reported to date. The quaternary assembly of soybean 7S basic globulin (Bg7S) is arranged as a cruciform-shaped tetramer comprised of two superposed dimers. Here, the crystal structure of γ-conglutin isolated fromLupinus angustifoliusseeds (LangC) is presented. The polypeptide chain of LangC is post-translationally cleaved into α and β subunits but retains its covalent integrity owing to a disulfide bridge. The protomers of LangC undergo an intricate quaternary assembly, resulting in a ring-like hexamer with noncrystallographicD3symmetry. The twofold-related dimers are similar to those in Bg7S but their assembly is different as a consequence of mutations in a β-strand that is involved in intermolecular β-sheet formation in γ-conglutin. Structural elucidation of γ-conglutin will help to explain its physiological role, especially in the evolutionary context, and will guide further research into the hypoglycaemic activity of this protein in humans, with potential consequences for novel antidiabetic therapies.</jats:p

Editorial: Legumes for global food security - volume II

JJ-L thanks the support of the European Research Program MARIE CURIE (FP7-PEOPLE-2011-IOF),grant ref. PIOF-GA- 2011-301550; the Spanish Ministry of Economy, Industry and Competitiveness (Ramon y Cajal Research Program), grant ref. RYC-2014-16536; the CSIC intramural research program, grant ref.202240I002; and the Spanish Ministry of Science and Innovation, grant ref. number CPP2021-008989. AC was supported by PY20_00242 grant, financed by the Consejeria de Trasnformación económica, Industria, Conocimiento y Universidades de la Junta de Andalucı́a (Spain) and FEDER funds A way to make Europ

Legumes for Global Food Security, volume II

Jiménez-López, J.C. (CSIC); Singh, K.B.; Clemente, A. (CSIC); Ochatt, S.; Von Wettberg, E.; Smykal, P.; Czubinski, J. Editor