Characteristics of the Manitoba Fracture Cohort Cases and Canadian Multicentre Osteoporosis Study (CaMos) Controls.

<p>Mean [SD] or Frequency (%).</p

Proportion of causal variants reaching significance as a function of the average effect and proportion of causal variants on average in a gene, employing a SNP-by-SNP analysis.

<p>Proportion of causal variants reaching significance as a function of the average effect and proportion of causal variants on average in a gene, employing a SNP-by-SNP analysis.</p

Description of the count of rare variants per gene.

<p>Description of the count of rare variants per gene.</p

Summary of phenotype simulations and hypotheses.

<p>Summary of phenotype simulations and hypotheses.</p

Dichotomous traits: Relationship between effect size, proportion of causal variants, and power, when causal variants only have a deleterious effect.

<p>Each box corresponds to a different proportion of causal variants involved in the relationship between rare variants and continuous traits (from left to right, 10, 15, 20 and 30%). On the x-axis, effect sizes are in standard deviations and correspond to the absolute value of the average size effect.</p

Dichotomous traits: Relationship between effect size, proportion of causal variants, and power, when causal variants are a mixture of protective and deleterious effects.

<p>Each box corresponds to a different proportion of causal variants involved in the relationship between rare variants and continuous traits (from left to right, 10, 15, 20 and 30%). On the x-axis, effect sizes are in standard deviations and correspond to the absolute value of the average size effect.</p

Continuous traits: Relationship between effect size, proportion of causal variants, and power.

<p>All causal variants have a deleterious effect. Each box corresponds to a different proportion of causal variants involved in the relationship between rare variants and continuous traits (from left to right, 10, 15, 20 and 30%). On the x-axis, effect sizes are in standard deviations and correspond to the absolute value of the average size effect.</p

Proportion of variance explained by rare variants.

<p>Proportion of variance explained by rare variants.</p

Description of the seven genes.

<p>Description of the seven genes.</p

Continuous traits: Relationship between effect size, proportion of causal variants, and power, when causal variants are a mixture of protective and deleterious effects.

<p>Each box corresponds to a different proportion of causal variants involved in the relationship between rare variants and continuous traits (from left to right, 10, 15, 20 and 30%). On the x-axis, effect sizes are in standard deviations and correspond to the absolute value of the average size effect.</p