64 research outputs found
Biological therapy of cancer
Interferons and monoclonal antibodies are among the most promising biological approaches to cancer treatment which have so far been investigated. Both natural and recombinant interferon-alpha preparations have shown activity in a number of trials in hematologic malignancies, even in previously treated patients; activity in solid tumors, however, has been limited. Unconjugated monoclonal antibodies have been safely administered in several small trials and have had therapeutic value on occasion. In spite of a number of remaining problems and questions, monoclonal antibodies and their conjugates seem likely to find a number of distinct roles in cancer treatment; elimination of micrometastases and purging of bone marrow for grafting may be among these roles.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44207/1/10549_2005_Article_BF01886730.pd
Specific elimination of cytotoxic effector cells. 1. Adsorptive behavior of effectors and their precursors on spleen cell monolayers.
Specific elimination of cytotoxic cells. II. Reduction of cytotoxic activity by adsorption on monolayers results from removal of cytotoxic cells and not from inhibition of their activity.
- …