Thyroidal angiogenesis in zebrafish (Danio rerio) exposed to high perchlorate concentration

WOS: 000266174000050As a well known environmental contaminant, perchlorate inhibits thyroidal iodide uptake and reduces thyroid hormone levels. In zebrafish (Danio rerio) exposed to high concentrations of sodium perchlorate (200, 350 and 500 mg/L) for 10 days, remarkable angiogenesis was identified, not only histopathologically but also statistically by counting of the small, medium and large sized (grades 1 to 3) vessels per unit area. Angiogenic response is concluded as the most sensitive parameter for rating of high concentrations of perchlorate exposure

Primary orbital neuroblastoma in a neonate

Neuroblastoma is an undifferentiated malignant tumor of the primitive neuroblasts. Orbital neuroblastoma is typically a metastatic tumor. We describe a two-days-old girl, who presented with a large tumor in her left orbit. Magnetic resonance imaging revealed that the tumor originated from the retrobulbar area, extending into the upper and lateral orbit. She was operated on the fifth day of life. A histopathologic diagnosis of neuroblastoma was made. Medical evaluation including chest roentgenogram, ultrasonography of the abdomen, whole body computerized tomogram and bone scintigraphy showed no evidence of systemic involvement or metastasis. Neuroblastoma should be considered in the differential diagnosis of neonatal orbital tumors

Correlation of IDH1, p53 and Ki-67 immunoexpression levels with morphological, clinical prognostic parameters and preoperative/postoperative radiological findings and response to treatment in high-grade glial tumor case

In this study, we aimed to investigate the prognostic factors affecting survival in adult patients with high-grade glial tumors. The retrospective study included 79 consecutive patients who were referred to our clinic for adjuvant radiotherapy/radiochemotherapy between 2010 and 2017. The effect of proposed prognostic factors on overall survival (OS) and disease-free survival (DFS) was evaluated with univariate and multivariate analyses. Median age was 56.63 (range, 24-84) years and the median Karnofsky Performance Status (KPS) at diagnosis was 89% (range, 50-100%). Most the cases (n=69; 87.1%)were histologically diagnosed as World Health Organization (WHO) grade IV. At a median follow-up of 12 months, OS and DFS were 12 and 8 months, respectively. Although age, KPS, IDH1, p53 and Ki-67 status were found to be statistically significant among the prognostic factors affecting OS in univariate analyses, only KPS, p53 and Ki-67 were statistically significant in multivariate analysis.In contrast, age, KPS, IDH1, and Ki-67 were found to be significant factors for DFS in univariate analysis, while only KPS and Ki-67 were found to be significant factors for DFS in multivariate analysis. KPS was the most important prognostic factor for OS and DFS. In the evaluation of postoperative histopathological findings, p53 and Ki-67 were found to be prognostic for OS while only Ki-67 was prognostic for DFS. However, IDH1, which is known as an important prognostic factor, did not have a significant prognostic value, which could be due to the limited number of cases in our study. [Med-Science 2023; 12(4.000): 1331-6

Lower Airway Inflammation in Nonasthmatic Allergic Rhinitis Patients

Objective: Allergic rhinitis and asthma have been considered as a single airway disease sharing a common pathophysiological mechanism of airway inflammation. We aimed to investigate the lower airway inflammation in allergic rhinitis patients without asthma. Material and Methods: Forty patients who referred to our tertiary care hospital's otorhinolaryngology clinic and diagnosed as moderate/severe persistent allergic rhinitis according to ARIA criteria were included in the study. After evaluation for the eligibility for the study, a nasal smear was taken, and rhinomanometry was performed to measure the nasal obstruction on visit 1. Twenty-four hours later from the visit 1, pulmonary functions including bronchial hyperactivity (BHR) were measured on visit 2. Twenty-four hours later from the visit 2, sputum induction was performed, and cell distribution of the sputums was evaluated. Results: Mean age of the 17 male and 23 female patients was 37 +/- 11. Nasal smear eosinophilia was studied in 36 of the patients and found positive in 36%. Nasal obstruction was demonstrated in 68% of the patients by rhinomanometry. BHR was positive in 30% of the participants. There was not any statistical significant relationship between nasal eosinophilia and nasal obstruction severity, BHR and induced sputum eosinophilia (p> 0.05). Among the induced sputums which were of good quality to be evaluated, 7.5% had an eosinophil ratio of 2%. Any relationship between induced sputum eosinophil percentages and FEV1, FEV1/FVC, nasal obstruction severity was not observed (p> 0.05). However, BHR was found to be significantly related with FEV1/FVC ratio which was >70% through the whole study population (r= 0.392 p= 0.012). Condusion: We could not demonstrate the expected relationship between nasal and lower airway inflammation markers in our study group of allergic rhinitis patients. This may be due to the small number of study population and strict exclusion of asthmatic patients as well as particularly the difficulties in standardization of the induced sputum technique

The Role of Endobronchial Biopsy in the Diagnosis of Pulmonary Sarcoidosis

OBJECTIVES: This study aimed to investigate the additional diagnostic value of endobronchial biopsy (EBB) in the diagnosis of pulmonary sarcoidosis