PENINGKATAN PARAMETER HEMORHEOLOGI DAN C-REACTIVE PROTEIN BERKORELASI DENGAN BERBAGAI DERAJAT STENOSIS JANTUNG KORONER

Background : Endotel dysfunction plays important role in the atherosclerosis formation before the inflammation process occurs. This endotel dysfunction is strongly related to the increment of blood viscosity (BV) thorough shear stress changes. C-reactive protein (CRP) is a biomarker inflammation and plays as a key in endotel dysfunction, formation and atherosclerosis plaque's progression. Objective : To know about the relation among BV and CRP with various degree of cardiac coronary stenosis. Method : There were twenty four patients with coronary heart disease who were taken angiography. BV levels were checked using Oswald viscometer and CRP by turbidimetric imunoassay. Angiography examination had been used to determine degree of coronary stenosis. The data had been analysed by using the Spearman correlation index. Result : The subject of this research consist of 17 men and 7 women with age in average of 55,96±7,29 years. It is found by angiography examination that there were 2 subjects (8,3%) non-significant stenosis, 22 others (91,7%) significant stenosis, and no one of them had normal stenosis. The correlation between BV and degree of coronary stenosis was moderate (r = 0,549; p = 0,005). The correlation between CRP and degree of coronary stenosis was moderate as well (r = 0,481; p = 0,017). Conclusion : There is an moderate positive correlation between BV and the degree of cardiac coronary stenosis. The similar correlation occurs between CRP and those degrees as well. Keywords : coronary heart disease, endotel dysfunction, C-reactive protein (CRP), blood viscosity, atherosclerosis, shear stress

Blood viscosity increases the degree of coronary stenosis in coronary heart disease

Background Endothelial dysfunction and associated increased blood viscosity (BV) play an important role in the formation of atherosclerosis during inflammatory processes. C-reactive protein (CRP) is a biomarker of inflammation with an active role in endothelial dysfunction and development of atherosclerosis that is marked by degree of coronary stenosis (CS). The purpose of this study was to determine the relationship of BV and CRP with varying degrees of CS among coronary heart disease (CHD) patients. Methods This cross-sectional study involved 24 subjects taken consecutively among patients with CHD who underwent angiography. Blood viscosity levels were determined using an Ostwald viscometer, with reference limits of 1.5 to 1.72 (cP). C-reactive protein was determined by turbidimetric immunoassay, with a normal reference value of 50% = significant stenosis. Data was analyzed using non-parametric Spearman correlation test. Results There were 17 male and 7 female subjects, with mean age of 55.96 ± 7.29 years. The angiography results were: non-significant stenosis in 2 subjects (8.3%), significant stenosis in 22 subjects (91.7%) and none with normal stenosis. Statistical analysis of the relationship of BV with degree of CS found a moderate significant positive relationship (r=0.549; p=0.005). A poor significant positive relationship was found between CRP and degree of CS (r=0.481; p=0.017). Conclusion Blood viscosity increased the degree of CS in CHD patients. Therapy should target both BV-associated risk and angiographically evident stenosis