Lupus induit et macro créatine kinase compliquant un traitement par mésalazine (à propos de six observations et revue de la littérature)

CLERMONT FD-BCIU-Santé (631132104) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Misrepresentation of Randomized Controlled Trials in Press Releases and News Coverage: A Cohort Study

<div><h3>Background</h3><p>Previous studies indicate that in published reports, trial results can be distorted by the use of “spin” (specific reporting strategies, intentional or unintentional, emphasizing the beneficial effect of the experimental treatment). We aimed to (1) evaluate the presence of “spin” in press releases and associated media coverage; and (2) evaluate whether findings of randomized controlled trials (RCTs) based on press releases and media coverage are misinterpreted.</p> <h3>Methods and Findings</h3><p>We systematically searched for all press releases indexed in the EurekAlert! database between December 2009 and March 2010. Of the 498 press releases retrieved and screened, we included press releases for all two-arm, parallel-group RCTs (<em>n</em> = 70). We obtained a copy of the scientific article to which the press release related and we systematically searched for related news items using Lexis Nexis.</p> <p>“Spin,” defined as specific reporting strategies (intentional or unintentional) emphasizing the beneficial effect of the experimental treatment, was identified in 28 (40%) scientific article abstract conclusions and in 33 (47%) press releases. From bivariate and multivariable analysis assessing the journal type, funding source, sample size, type of treatment (drug or other), results of the primary outcomes (all nonstatistically significant versus other), author of the press release, and the presence of “spin” in the abstract conclusion, the only factor associated, with “spin” in the press release was “spin” in the article abstract conclusions (relative risk [RR] 5.6, [95% CI 2.8–11.1], <em>p</em><0.001). Findings of RCTs based on press releases were overestimated for 19 (27%) reports. News items were identified for 41 RCTs; 21 (51%) were reported with “spin,” mainly the same type of “spin” as those identified in the press release and article abstract conclusion. Findings of RCTs based on the news item was overestimated for ten (24%) reports.</p> <h3>Conclusion</h3><p>“Spin” was identified in about half of press releases and media coverage. In multivariable analysis, the main factor associated with “spin” in press releases was the presence of “spin” in the article abstract conclusion.</p> </div

Bivariate analysis of factors associated with and “spin” in the press releases.

<p>Bivariate analysis of factors associated with and “spin” in the press releases.</p

General characteristics of articles.

a<p>Adequately, with effect size and precision or treatment effect in each arm with precision.</p>b<p>Numbers do not add up as the types of “spin” were not mutually exclusive.</p

Flow diagram of the selected press releases and related articles.

<p>Flow diagram of the selected press releases and related articles.</p

General characteristics of press releases.

a<p>Numbers do not add up as the types of “spin” were not mutually exclusive.</p

Examples of “spin” in abstracts, in press releases, and in related news items.

<p>Examples of “spin” in abstracts, in press releases, and in related news items.</p

Bivariate analysis of factors associated with an overestimation of the benefit of the experimental treatment from the press releases as compared with the interpretation from articles.

<p>Bivariate analysis of factors associated with an overestimation of the benefit of the experimental treatment from the press releases as compared with the interpretation from articles.</p

“Spin” in abstract conclusions, press releases, and news items.

<p>“Spin” in abstract conclusions, press releases, and news items.</p