Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing.

In this study we investigated how hemostats such as oxidized regenerated cellulose (ORC, TABOTAMP) and oxidized non-regenerated cellulose (ONRC, RESORBA CELL) influence local cellular behavior and contraction of the extracellular matrix (ECM). Human stromal fibroblasts were inoculated in vitro with ORC and ONRC. Cell proliferation was assayed over time, and migration was evaluated by Live Cell imaging microscopy. Fibroblasts grown in collagen-gels were treated with ORC or ONRC, and ECM contraction was measured utilizing a contraction assay. An absolute pH decline was observed with both ORC and ONRC after 1 hour. Mean daily cell proliferation, migration and matrix contraction were more strongly inhibited by ONRC when compared with ORC (p < 0.05). When control media was pH-lowered to match the lower pH values typically seen with ORC and ONRC, significant differences in cell proliferation and migration were still observed between ONRC and ORC (p < 0.05). However, in these pH conditions, inhibition of matrix contraction was only significant for ONRC (p < 0.05). We find that ORC and ONRC inhibit fibroblast proliferation, migration and matrix contraction, and stronger inhibition of these essential cellular processes of wound healing were observed for ONRC when compared with ORC. These results will require further validation in future in vivo experiments to clarify the clinical implications for hemostat use in post-surgical wound healing

Verfahren zum Steuern einer Relaisstation in einem Mobilfunknetzwerk

DE 102008009087 A1 UPAB: 20090928 NOVELTY - The method involves receiving bandwidth requirements from terminals (150,160,170) by a broadcasting station (140). An aggregated bandwidth requirement is determined by the broadcasting station. The aggregated bandwidth requirement is sent from the broadcasting station to base stations (110,120). An aggregated bandwidth authorization is received by the broadcasting station from the base stations. DETAILED DESCRIPTION - INDEPENDENT CLAIMS are included for the following: (1) a computer program product with a program code for executing a controlling method of a broadcasting station of a portable radio network; and (2) a system consisting of two broadcasting stations. USE - Method for controlling a broadcasting station of a portable radio network (Claimed). ADVANTAGE - The aggregated bandwidth requirement is determined by the broadcasting station and the aggregated bandwidth requirement is sent from the broadcasting station to base stations, and hence enables to receive and send the data traffic between the base station and one or more terminals wirelessly

Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing.

In this study we investigated how hemostats such as oxidized regenerated cellulose (ORC, TABOTAMP) and oxidized non-regenerated cellulose (ONRC, RESORBA CELL) influence local cellular behavior and contraction of the extracellular matrix (ECM). Human stromal fibroblasts were inoculated in vitro with ORC and ONRC. Cell proliferation was assayed over time, and migration was evaluated by Live Cell imaging microscopy. Fibroblasts grown in collagen-gels were treated with ORC or ONRC, and ECM contraction was measured utilizing a contraction assay. An absolute pH decline was observed with both ORC and ONRC after 1 hour. Mean daily cell proliferation, migration and matrix contraction were more strongly inhibited by ONRC when compared with ORC (p < 0.05). When control media was pH-lowered to match the lower pH values typically seen with ORC and ONRC, significant differences in cell proliferation and migration were still observed between ONRC and ORC (p < 0.05). However, in these pH conditions, inhibition of matrix contraction was only significant for ONRC (p < 0.05). We find that ORC and ONRC inhibit fibroblast proliferation, migration and matrix contraction, and stronger inhibition of these essential cellular processes of wound healing were observed for ONRC when compared with ORC. These results will require further validation in future in vivo experiments to clarify the clinical implications for hemostat use in post-surgical wound healing