The Workers' Compensation System of British Columbia: Still in Transition

This inventory addresses eight core issues in the British Columbia workers' compensation system:* How is the system administered?* How do claims flow through the system?* What dispute resolution procedures are used, and to what effect?* What benefits are paid?* How are vocational rehabilitation services provided?* How is the system financed?* What are the actual costs of administration, benefits, claims processing, and appeal?* What aspects of the system deserve further attention

How robust is the evidence of an emerging or increasing female excess in physical morbidity between childhood and adolescence? Results of a systematic literature review and meta-analyses

For asthma and psychological morbidity, it is well established that higher prevalence among males in childhood is replaced by higher prevalence among females by adolescence. This review investigates whether there is evidence for a similar emerging female ‘excess’ in relation to a broad range of physical morbidity measures. Establishing whether this pattern is generalised or health outcome-specific will further understandings of the aetiology of gender differences in health. Databases (Medline; Embase; CINAHL; PsycINFO; ERIC) were searched for English language studies (published 1992–2010) presenting physical morbidity prevalence data for males and females, for at least two age-bands within the age-range 4–17 years. A three-stage screening process (initial sifting; detailed inspection; extraction of full papers), was followed by study quality appraisals. Of 11 245 identified studies, 41 met the inclusion criteria. Most (n = 31) presented self-report survey data (five longitudinal, 26 cross-sectional); 10 presented routinely collected data (GP/hospital statistics). Extracted data, supplemented by additional data obtained from authors of the included studies, were used to calculate odds ratios of a female excess, or female:male incident rate ratios as appropriate. To test whether these changed with age, the values were logged and regressed on age in random effects meta-regressions. These showed strongest evidence of an emerging/increasing female excess for self-reported measures of headache, abdominal pain, tiredness, migraine and self-assessed health. Type 1 diabetes and epilepsy, based on routinely collected data, did not show a significant emerging/increasing female excess. For most physical morbidity measures reviewed, the evidence broadly points towards an emerging/increasing female excess during the transition to adolescence, although results varied by morbidity measure and study design, and suggest that this may occur at a younger age than previously thought

The bldC developmental locus of Streptomyces coelicolor encodes a member of a family of small DNA-binding proteins related to the DNA-binding domains of the MerR family.

The bldC locus, required for formation of aerial hyphae in Streptomyces coelicolor, was localized by map-based cloning to the overlap between cosmids D17 and D25 of a minimal ordered library. Subcloning and sequencing showed that bldC encodes a member of a previously unrecognized family of small (58- to 78-residue) DNA-binding proteins, related to the DNA-binding domains of the MerR family of transcriptional activators. BldC family members are found in a wide range of gram-positive and gram-negative bacteria. Constructed {Delta}bldC mutants were defective in differentiation and antibiotic production. They failed to form an aerial mycelium on minimal medium and showed severe delays in aerial mycelium formation on rich medium. In addition, they failed to produce the polyketide antibiotic actinorhodin, and bldC was shown to be required for normal and sustained transcription of the pathway-specific activator gene actII-orf4. Although {Delta}bldC mutants produced the tripyrrole antibiotic undecylprodigiosin, transcripts of the pathway-specific activator gene (redD) were reduced to almost undetectable levels after 48 h in the bldC mutant, in contrast to the bldC+ parent strain in which redD transcription continued during aerial mycelium formation and sporulation. This suggests that bldC may be required for maintenance of redD transcription during differentiation. bldC is expressed from a single promoter. S1 nuclease protection assays and immunoblotting showed that bldC is constitutively expressed and that transcription of bldC does not depend on any of the other known bld genes. The bldC18 mutation that originally defined the locus causes a Y49C substitution that results in instability of the protein

From gas to galaxies

The unsurpassed sensitivity and resolution of the Square Kilometer Array (SKA) will make it possible for the first time to probe the continuum emission of normal star forming galaxies out to the edges of the universe. This opens the possibility for routinely using the radio continuum emission from galaxies for cosmological research as it offers an independent probe of the evolution of the star formation density in the universe. In addition it offers the possibility to detect the first star forming objects and massive black holes. In deep surveys SKA will be able to detect HI in emission out to redshifts of $z \approx 2.5$ and hence be able to trace the conversion of gas into stars over an era where considerable evolution is taking place. Such surveys will be able to uniquely determine the respective importance of merging and accreting gas flows for galaxy formation over this redshift range (i.e. out to when the universe was only one third its present age). It is obvious that only SKA will able to see literally where and how gas is turned into stars. These and other aspects of SKA imaging of galaxies will be discussed.Comment: To be published in New Astronomy Reviews, Elsevier, Amsterdam as part of "Science with the Square Kilometre Array", eds. C. Carilli and S. Rawlings. 18 pages + 13 figures; high resolution version and other chapters of "Science with the Square Kilometre Array" available at http://www.skatelescope.org/pages/science_gen.ht

Hopping Conduction and Bacteria: Transport in Disordered Reaction-Diffusion Systems

We report some basic results regarding transport in disordered reaction-diffusion systems with birth (A->2A), death (A->0), and binary competition (2A->A) processes. We consider a model in which the growth process is only allowed to take place in certain areas--"oases"--while the rest of space--the "desert"--is hostile to growth. In the limit of low oasis density, transport is mediated through rare "hopping" events, necessitating the inclusion of discreteness effects in the model. By first considering transport between two oases, we are able to derive an approximate expression for the average time taken for a population to traverse a disordered medium.Comment: 4 pages, 2 figure