Sacred Romance: A Pageant on the Romance (in the Life of a Priest)

A distant peal of the jubilee bells for a pastor\u27s silver anniversary awakened the inspiration for the theme of my pageant on Sacred Romance. I selected this form of drama since pageant creation offers the combined use of the contributory arts of language, of action, of color, of music; and because I felt that pageantry would be the best medium through which to review the sacred beauty of the church, its sacraments and priesthood. The episodes were selected to review sacred romance in the life of a priest in such a manner as to inspire the audience with a greater appreciation for the sanctity and value of the Catholic priesthood. And I hoped to awaken a true realization of the laity\u27s duty to assist with their prayers in keeping a priest a holy man, in making him a successful missionary of God in his life of continual sacrifice. In the production of Sacred Romance, I endeavored to inspire my large cast of one hundred and seventy-five eager school children with a love of the artistic and sacred; to lead each to realize his importance in contributing to the success of the dramatic project; to encourage the development of artistic talent

4 Co-Creating Value in Systems Development: A Shift towards Service- Dominant Logic 2012 AITP Education Special Interest Group (EDSIG) Board of Directors Journal of Information Systems Applied Research Editors JISAR Editorial Board Maximizing Visibility i

The journal acceptance review process involves a minimum of three double-blind peer reviews, where both the reviewer is not aware of the identities of the authors and the authors are not aware of the identities of the reviewers. The initial reviews happen before the conference. At that point papers are divided into award papers (top 15%), other journal papers (top 30%), unsettled papers, and non-journal papers. The unsettled papers are subjected to a second round of blind peer review to establish whether they will be accepted to the journal or not. Those papers that are deemed of sufficient quality are accepted for publication in the JISAR journal. Currently the target acceptance rate for the journal is about 45%. Questions should be addressed to the editor at [email protected] or the publisher at [email protected]. AITP Education Special Interest Group (EDSIG) Board of Directors Abstract Given a new product (a tuple), the research in this paper considers the problem of selecting a small subset of attributes to highlight such that the product stands out in a crowd of existing competitive products and is widely visible to the pool of potential customers. This problem has applications in marketing and product manufacturing and has been the subject of recent investigations. This research considers an important variant where a product is considered to be visible to a customer if it occurs in the skyline of the query posed by the customer. Given a set of d-dimensional points, a skyline query returns points that are not dominated by any other point on all dimensions. This problem variant poses new challenges that cannot be solved optimally using prior techniques. In this work, we develop a novel optimal algorithm based on the Signature Tree data structure as well as approximation algorithms to solve the problem. We conduct a performance study illustrating the benefits of our methods on real as well as synthetic data

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice

<div><p>The purpose of this work was to use various molecular imaging techniques to non-invasively assess GSK2849330 (anti HER3 ADCC and CDC enhanced ‘AccretaMab’ monoclonal antibody) pharmacokinetics and pharmacodynamics in human xenograft tumor-bearing mice. Immuno-PET biodistribution imaging of radiolabeled ⁸⁹Zr-GSK2849330 was assessed in mice with HER3 negative (MIA-PaCa-2) and positive (CHL-1) human xenograft tumors. Dose dependency of GSK2849330 disposition was assessed using varying doses of unlabeled GSK2849330 co-injected with ⁸⁹Zr-GSK2849330. In-vivo NIRF optical imaging and ex-vivo confocal microscopy were used to assess the biodistribution of GSK2849330 and the HER3 receptor occupancy in HER3 positive xenograft tumors (BxPC3, and CHL-1). Ferumoxytol (USPIO) contrast-enhanced MRI was used to investigate the effects of GSK2849330 on tumor macrophage content in CHL-1 xenograft bearing mice. Immuno-PET imaging was used to monitor the whole body drug biodistribution and CHL-1 xenograft tumor uptake up to 144 hours post injection of ⁸⁹Zr-GSK2849330. Both hepatic and tumor uptake were dose dependent and saturable. The optical imaging data in the BxPC3 xenograft tumor confirmed the tumor dose response finding in the Immuno-PET study. Confocal microscopy showed a distinguished cytoplasmic punctate staining pattern within individual CHL-1 cells. GSK2849330 inhibited tumor growth and this was associated with a significant decrease in MRI signal to noise ratio after USPIO injection and with a significant increase in tumor macrophages as confirmed by a quantitative immunohistochemistry analysis. By providing both dose response and time course data from both ⁸⁹Zr and fluorescently labeled GSK2849330, complementary imaging studies were used to characterize GSK2849330 biodistribution and tumor uptake in vivo. Ferumoxytol-enhanced MRI was used to monitor aspects of the immune system response to GSK2849330. Together these approaches potentially provide clinically translatable, non-invasive techniques to support dose optimization, and assess immune activation and anti-tumor responses.</p></div