Time course of the change in hind paw volume after the induction of arthritis

<p><b>Copyright information:</b></p><p>Taken from "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat"</p><p>http://arthritis-research.com/content/9/5/R91</p><p>Arthritis Research & Therapy 2007;9(5):R91-R91.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2212551.</p><p></p> Rats in all arthritic groups showed an increase in their paw volume until day 8; however, this increase in the azothioprine (AZ)-treated, chloroquine (CQ)-treated and sodium aurothiomalate (gold salt (GS))-treated arthritic rats was not significantly different from the normal control rats, and also no further increase in the paw volume was noticed in these groups. In contrast, arthritic rats treated with methotrexate (MTX) and indomethacine showed a gradual increase in their paw volume over a period of 22 days, but this increase was nonsignificant compared with normal control rats. The arthritic rats treated with D-penicillamine (D-PEN) or saline showed a significant increase in their paw volume over the period of 22 days (< 0.006). Inbox pictures, difference between the arthritic rat paw and the normal rat paw. Results expressed as mean ± standard error (= 6). AC, arthritic control; AIA, adjuvant-induced arthritis; DC, drug control; NT, no treatment; Sal + Art, saline and arthritis

Time course of body weight changes in rats with adjuvant-induced arthritis

<p><b>Copyright information:</b></p><p>Taken from "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat"</p><p>http://arthritis-research.com/content/9/5/R91</p><p>Arthritis Research & Therapy 2007;9(5):R91-R91.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2212551.</p><p></p> Effect of disease-modifying antirheumatic drugs (DMARDs) on the body weight change of the arthritic rats, measured over a period of 22 days. Effect of D-penicillamine (D-PEN) and sodium aurothiomalate (gold salt (GS)) on body weights of adjuvant-induced arthritis (AIA) rats. Effect of azothioprine (AZ), chloroquine (CQ) and methotrexate (MTX) on body weights of AIA rats. Results are the mean ± standard error for six animals per group. AC, arthritic control; DC, drug control; NT, no treatment; Sal + Art, saline and arthritis

Arthritis severity scores in rats during the development of adjuvant-induced arthritis

<p><b>Copyright information:</b></p><p>Taken from "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat"</p><p>http://arthritis-research.com/content/9/5/R91</p><p>Arthritis Research & Therapy 2007;9(5):R91-R91.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2212551.</p><p></p> Effect of azothioprine (AZ), chloroquine (CQ), D-penicillamine (D-PEN), sodium aurothiomalate (gold salt (GS)) and methotrexate (MTX) on the time course of the development and progression of arthritis, shown as the arthritis severity scores measured over a period of 22 days. Results are the mean ± standard error for six animals in each group. AIA, adjuvant-induced arthritis; DC, drug control; NT, no treatment

Time course of walking speed changes after the induction of arthritis compared with normal rats

<p><b>Copyright information:</b></p><p>Taken from "Quantitative gait analysis as a method to assess mechanical hyperalgesia modulated by disease-modifying antirheumatoid drugs in the adjuvant-induced arthritic rat"</p><p>http://arthritis-research.com/content/9/5/R91</p><p>Arthritis Research & Therapy 2007;9(5):R91-R91.</p><p>Published online 11 Sep 2007</p><p>PMCID:PMC2212551.</p><p></p> Treated arthritic rats or untreated arthritic rats showed a gradual decrease in velocity from day 2 onwards. Arthritic rats treated with azothioprine (AZ), chloroquine (CQ), sodium aurothiomalate (gold salt (GS)), methotrexate (MTX) and indomethacine, however, exhibited a reversal of the deficit in velocity seen in the untreated rats or saline-treated arthritic rats from day 12 onwards. Results are the mean ± standard error (= 6). AC, arthritic control; AIA, adjuvant-induced arthritis; DC, drug control; NT, no treatment; Sal + Art, saline and arthritis