津田修二:先天性臍帶ヘルニアに就て 正誤表(第11卷 第3號 綜説欄所載)

The primary 2-DE gel maps at least three biological replicates for control, dehydration treatments (18 h, 24 h and 48 h) and rehydration treatment (R24 h) in Longchun 23. (TIF 1707 kb

Three-Dimensional Bioprinting of Oppositely Charged Hydrogels with Super Strong Interface Bonding

A novel strategy to improve the adhesion between printed layers of three-dimensional (3D) printed constructs is developed by exploiting the interaction between two oppositely charged hydrogels. Three anionic hydrogels [alginate, xanthan, and κ-carrageenan (Kca)] and three cationic hydrogels [chitosan, gelatin, and gelatin methacrylate (GelMA)] are chosen to find the optimal combination of two oppositely charged hydrogels for the best 3D printability with strong interface bonding. Rheological properties and printability of the hydrogels, as well as structural integrity of printed constructs in cell culture medium, are studied as functions of polymer concentration and the combination of hydrogels. Kca2 (2 wt % Kca hydrogel) and GelMA10 (10 wt % GelMA hydrogel) are found to be the best combination of oppositely charged hydrogels for 3D printing. The interfacial bonding between a Kca layer and a GelMA layer is proven to be significantly higher than that of the bilayered Kca or bilayered GelMA because of the formation of polyelectrolyte complexes between the oppositely charged hydrogels. A good cell viability of >96% is obtained for the 3D-bioprinted Kca–GelMA construct. This novel strategy has a great potential for 3D bioprinting of layered constructs with a strong interface bonding

Three-Dimensional Bioprinting of Oppositely Charged Hydrogels with Super Strong Interface Bonding

A novel strategy to improve the adhesion between printed layers of three-dimensional (3D) printed constructs is developed by exploiting the interaction between two oppositely charged hydrogels. Three anionic hydrogels [alginate, xanthan, and κ-carrageenan (Kca)] and three cationic hydrogels [chitosan, gelatin, and gelatin methacrylate (GelMA)] are chosen to find the optimal combination of two oppositely charged hydrogels for the best 3D printability with strong interface bonding. Rheological properties and printability of the hydrogels, as well as structural integrity of printed constructs in cell culture medium, are studied as functions of polymer concentration and the combination of hydrogels. Kca2 (2 wt % Kca hydrogel) and GelMA10 (10 wt % GelMA hydrogel) are found to be the best combination of oppositely charged hydrogels for 3D printing. The interfacial bonding between a Kca layer and a GelMA layer is proven to be significantly higher than that of the bilayered Kca or bilayered GelMA because of the formation of polyelectrolyte complexes between the oppositely charged hydrogels. A good cell viability of >96% is obtained for the 3D-bioprinted Kca–GelMA construct. This novel strategy has a great potential for 3D bioprinting of layered constructs with a strong interface bonding

Guest Molecule Release Triggers Changes in the Catalytic and Magnetic Properties of a Fe^II-Based 3D Metal–Organic Framework

A Fe^II-based metal–organic framework (MOF), {[Fe₂(pbt)₂(H₂O)₂]·2H₂O}_<i>n</i>, undergoes an irreversible dehydration, which triggers changes in the catalytic and magnetic properties of the MOF. These property changes are attributed to the high-spin to low-spin transition of 7.1% center Fe^II, which is demonstrated by ⁵⁷Fe Mössbauer, X-ray photoelectron spectroscopy, and UV/vis absorption spectra

Structural Diversity for a Series of Novel Zn Metal–Organic Frameworks Based on Different Secondary Building Units

The secondary building unit (SBU) has been identified as a useful tool in the synthesis of metal–organic frameworks (MOFs). Herein, we synthesized six novel Zn complexes, namely, {[Zn₃(tci)₂(DMF)₂)]·2DMF·2CH₃OH}_<i>n</i> (<b>1</b>), {[Zn₃(tci)₂(DMSO)₂(H₂O)₂]·2DMSO·3H₂O}_<i>n</i> (<b>2</b>), {[ZnNa­(tci)­(H₂O)]·2H₂O}_<i>n</i> (<b>3</b>), {[Zn₅(tci)₂(OH)₄(H₂O)₂]·2H₂O}_<i>n</i> (<b>4</b>), {[Zn₃(tci)₂(phen)₂(H₂O)₂]·4H₂O}_<i>n</i> (<b>5</b>), and {[Zn₃(tci)₂(btb)₂(H₂O)₂]·6H₂O}_<i>n</i> (<b>6</b>) by utilizing different SBUs (tci = tris­(2-carboxyethyl) isocyanurate, phen = 1,10-phenanthroline, btb = 1,4-bis (1,2,4-triazole-1-ylmethyl) benzene). Complexes <b>1</b>–<b>4</b> were synthesized only by changing solvents, and complexes <b>5</b> and <b>6</b> were obtained by adding different auxiliary ligands on the same conditions. Structural analyses show that complexes <b>1</b> and <b>2</b> possess two-dimensional (2D) structures based on linear and triangular trinuclear Zn clusters. Complexes <b>3</b> and <b>4</b> exhibit 2D and three-dimensional (3D) frameworks built on rare infinite rod-shaped SBUs, while complex <b>5</b> belongs to a 3D framework with two kinds of left- and right-helical chains built from discrete dinuclear Zn clusters and mononuclear Zn atoms. Complex <b>6</b> exhibits high-connected 3D framework based on extended linear trinuclear Zn clusters

DataSheet1_Comparative differences in the risk of major gastrointestinal bleeding among different direct oral anticoagulants: An updated traditional and Bayesian network meta-analysis.PDF

Background: The most favorable gastrointestinal (GI) bleeding safety profile among different types of direct oral anticoagulants (DOACs) remains controversial. This meta-analysis includes the latest studies and aims to compare GI bleeding risk associated with the use of various DOACs.Methods: PubMed, Cochrane library, and clinicaltrial.gov were searched. Randomized control trials (RCTs) evaluating the safety of DOACs were identified. The primary endpoint assessed was major GI bleeding.Results: A total of 37 RCTs were included in the analyses. Based on the traditional meta-analysis, the major GI bleeding risk was different among various DOACs (interactive p-value Conclusion: Differences in the major GI bleeding risk were observed when various DOACs were compared. Among standard-dose DOACs, apixaban was associated with the lowest degree of major GI risk. Among low-dose DOACs, edoxaban was associated with a lower major GI bleeding risk than rivaroxaban.</p

Template-Assisted Synthesis of Co,Mn-MOFs with Magnetic Properties Based on Pyridinedicarboxylic Acid

To investigate the influence of organic molecules with reactive functional groups as templates on the structures of the resulting MOFs, four novel complexes based on the pyridyl carboxylic acid ligand 5-(pyridin-4-yl)­isophthalic acid (H₂pyip), namely, [Mn₃(pyip)₂(HCOO)₂(H₂O)₂]_<i>n</i> (<b>1</b>), {[Co­(pyip)­(H₂O)]·H₂O}_<i>n</i> (<b>2</b>), {[Mn₂(pyip)₂(H₂O)₄]·5H₂O}_<i>n</i> (<b>3</b>), and [Co­(pyip)­(EtOH)­(H₂O)]_<i>n</i> (<b>4</b>), have been synthesized under solvothermal conditions. In the presence of 4,4′-bipyridyl as the template, 3D coordination framework <b>1</b> with the Schläfli symbol of (4·6·7) (4²·5·6⁵·7³·8²·9·11) was obtained. Using cyanoacetic acid as the template, we obtained 2D double-layered structure <b>2</b> with the Schläfli symbol of (4³) (4⁶·6⁶·8³). <b>3</b> and <b>4</b> are prepared in the absence of a templating agent. <b>3</b> features an infinite 2D network with a 1D water chain penetrating the 1D channel and further results in a 3D supramolecule through hydrogen-bond interactions. <b>4</b> contains two independent 2D networks that are further connected to a 2D double-layered supramolecular framework by hydrogen bonds. The template-assisted method is a potential approach for obtaining specific intriguing complexes that might be difficult to access by routine synthetic methods. Magnetic investigations revealed that both <b>1</b> and <b>2</b> exhibit weak antiferromagnetic interactions mediated by pyip^2–

Template-Assisted Synthesis of Co,Mn-MOFs with Magnetic Properties Based on Pyridinedicarboxylic Acid

To investigate the influence of organic molecules with reactive functional groups as templates on the structures of the resulting MOFs, four novel complexes based on the pyridyl carboxylic acid ligand 5-(pyridin-4-yl)­isophthalic acid (H₂pyip), namely, [Mn₃(pyip)₂(HCOO)₂(H₂O)₂]_<i>n</i> (<b>1</b>), {[Co­(pyip)­(H₂O)]·H₂O}_<i>n</i> (<b>2</b>), {[Mn₂(pyip)₂(H₂O)₄]·5H₂O}_<i>n</i> (<b>3</b>), and [Co­(pyip)­(EtOH)­(H₂O)]_<i>n</i> (<b>4</b>), have been synthesized under solvothermal conditions. In the presence of 4,4′-bipyridyl as the template, 3D coordination framework <b>1</b> with the Schläfli symbol of (4·6·7) (4²·5·6⁵·7³·8²·9·11) was obtained. Using cyanoacetic acid as the template, we obtained 2D double-layered structure <b>2</b> with the Schläfli symbol of (4³) (4⁶·6⁶·8³). <b>3</b> and <b>4</b> are prepared in the absence of a templating agent. <b>3</b> features an infinite 2D network with a 1D water chain penetrating the 1D channel and further results in a 3D supramolecule through hydrogen-bond interactions. <b>4</b> contains two independent 2D networks that are further connected to a 2D double-layered supramolecular framework by hydrogen bonds. The template-assisted method is a potential approach for obtaining specific intriguing complexes that might be difficult to access by routine synthetic methods. Magnetic investigations revealed that both <b>1</b> and <b>2</b> exhibit weak antiferromagnetic interactions mediated by pyip^2–

Template-Assisted Synthesis of Co,Mn-MOFs with Magnetic Properties Based on Pyridinedicarboxylic Acid

To investigate the influence of organic molecules with reactive functional groups as templates on the structures of the resulting MOFs, four novel complexes based on the pyridyl carboxylic acid ligand 5-(pyridin-4-yl)­isophthalic acid (H₂pyip), namely, [Mn₃(pyip)₂(HCOO)₂(H₂O)₂]_<i>n</i> (<b>1</b>), {[Co­(pyip)­(H₂O)]·H₂O}_<i>n</i> (<b>2</b>), {[Mn₂(pyip)₂(H₂O)₄]·5H₂O}_<i>n</i> (<b>3</b>), and [Co­(pyip)­(EtOH)­(H₂O)]_<i>n</i> (<b>4</b>), have been synthesized under solvothermal conditions. In the presence of 4,4′-bipyridyl as the template, 3D coordination framework <b>1</b> with the Schläfli symbol of (4·6·7) (4²·5·6⁵·7³·8²·9·11) was obtained. Using cyanoacetic acid as the template, we obtained 2D double-layered structure <b>2</b> with the Schläfli symbol of (4³) (4⁶·6⁶·8³). <b>3</b> and <b>4</b> are prepared in the absence of a templating agent. <b>3</b> features an infinite 2D network with a 1D water chain penetrating the 1D channel and further results in a 3D supramolecule through hydrogen-bond interactions. <b>4</b> contains two independent 2D networks that are further connected to a 2D double-layered supramolecular framework by hydrogen bonds. The template-assisted method is a potential approach for obtaining specific intriguing complexes that might be difficult to access by routine synthetic methods. Magnetic investigations revealed that both <b>1</b> and <b>2</b> exhibit weak antiferromagnetic interactions mediated by pyip^2–

Data_Sheet_1_Clinical benefit of sodium-glucose transport protein-2 inhibitors in patients with heart failure: An updated meta-analysis and trial sequential analysis.PDF

To assess whether the current body of accumulated data can give convincing evidence in favor of sodium-glucose transport protein-2 inhibitor (SGLT-2i) in all types of heart failure (HF). We searched for randomized controlled trials contrasting the effectiveness of SGLT-2i to placebo or other hypoglycemic medications on clinicaltrials.gov, PubMed, and the Cochrane Library database. To gauge effect size, hazard ratios (HR) were employed as measurements. The composite outcome of cardiovascular death or hospitalization owing to HF was the primary endpoint. Eleven studies were included. In comparison to the control group, the data demonstrated that SGLT-2i is related with a decreased incidence of composite outcome (HR: 0.77, 95% CIs: 0.73–0.81, I2 = 0%, P 2 = 3%, P 2 = 10%, P 2 = 0%, P Systematic review registration[https://www.crd.york.ac.uk/prospero/#recordDetails], identifier [CRD42022333279].</p