Additional file 1 of Dopamine enhances recovery after traumatic brain injury through ubiquitylation and autophagic degradation of RIPK1

Additional file 1: Supplementary Table 1. Clinical information of human brain specimens. Supplemental fig 1. Assessment of siRNA on Drd1, Drd2, Drd3, Drd4 and Drd5. Supplemental fig 2. Assessment of E3 ligase proteins

CuX Dual Catalysis: Construction of Oxazolo[2,3‑<i>b</i>][1,3]oxazines via a Tandem CuAAC/Ring Cleavage/[4+2+3] Annulation Reaction

CuX as a simple dual catalyst strategy that promotes the tandem transformations of fused oxazolo[2,3-b][1,3]oxazines has been developed. Copper catalyzed terminal ynones, sulfonyl azides, and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction, while the halogen catalyzed ring cleavage and [2+3] annulation of oxiranes to form the final fused products. This study provides a four-component, one-pot strategy for synthesizing complex fused heterocycles from simple ingredients and expands the application of CuAAC in organic synthesis

Pt/Zeolite Catalysts for Soot Oxidation: Influence of Hydrothermal Aging

Developments in diesel engines and gasoline direct injection (GDI) engines have spawned the requirement of soot oxidation catalysts that work well in both NO + O₂ and O₂. In this study, we found that supporting Pt on zeolites such as H-ZSM5 and USY may receive better soot oxidizers than commercial Pt/Al₂O₃ catalyst. Durability tests indicate that, even after the hydrothermal aging at 800 °C, the aged Pt/H-ZSM5 is still a better soot oxidizer than Pt/Al₂O₃ in NO + O₂, and the aged Pt/USY exhibits the best activity in O₂. Further explorations reveal that the NO₂ preferential adsorption on soot is dependent on acid sites both inside and outside micropores of zeolites, while the decomposition of surface oxygenated complexes (SOCs) can be promoted by strong acid sites on the external surface. These two factors contribute mainly to the high activity of the Pt/zeolite catalysts in NO + O₂ and O₂, respectively. Considering a relatively high external surface area is always essential to inhibiting the severe sintering of Pt, it is important to choose a zeolite support with a relatively large external surface area and a certain amount of acid sites after the hydrothermal aging

CuX Dual Catalysis: Construction of Oxazolo[2,3‑<i>b</i>][1,3]oxazines via a Tandem CuAAC/Ring Cleavage/[4+2+3] Annulation Reaction

CuX as a simple dual catalyst strategy that promotes the tandem transformations of fused oxazolo[2,3-b][1,3]oxazines has been developed. Copper catalyzed terminal ynones, sulfonyl azides, and nitriles for the CuAAC/ring cleavage/[4+2] annulation reaction, while the halogen catalyzed ring cleavage and [2+3] annulation of oxiranes to form the final fused products. This study provides a four-component, one-pot strategy for synthesizing complex fused heterocycles from simple ingredients and expands the application of CuAAC in organic synthesis

The prognostic value of HER2 in ovarian cancer: A meta-analysis of observational studies - Fig 6

<p><b>6A.</b> Begg’s publication bias plot of the studies assessing HER2 expression and overall survival in ovarian cancer. <b>6B.</b> Begg’s publication bias plot of the studies assessing HER2 expression and disease-free survival / progress-free survival in ovarian cancer. Visual inspection of the funnel plot did not identify substantial asymmetry.</p

Forest plots of HR and 95%CI for disease-free survival / progress-free survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

Forest plots of HR and 95%CI for disease-free survival / progress-free survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

PRISMA flow chart of literature search and study selection.

<p>PRISMA flow chart of literature search and study selection.</p

Forest plots of HR and 95%CI for overall survival in ovarian cancer according to presence of HER2.

<p>Random-effects model was used.</p

Pt/Zeolite Catalysts for Soot Oxidation: Influence of Hydrothermal Aging

Developments in diesel engines and gasoline direct injection (GDI) engines have spawned the requirement of soot oxidation catalysts that work well in both NO + O₂ and O₂. In this study, we found that supporting Pt on zeolites such as H-ZSM5 and USY may receive better soot oxidizers than commercial Pt/Al₂O₃ catalyst. Durability tests indicate that, even after the hydrothermal aging at 800 °C, the aged Pt/H-ZSM5 is still a better soot oxidizer than Pt/Al₂O₃ in NO + O₂, and the aged Pt/USY exhibits the best activity in O₂. Further explorations reveal that the NO₂ preferential adsorption on soot is dependent on acid sites both inside and outside micropores of zeolites, while the decomposition of surface oxygenated complexes (SOCs) can be promoted by strong acid sites on the external surface. These two factors contribute mainly to the high activity of the Pt/zeolite catalysts in NO + O₂ and O₂, respectively. Considering a relatively high external surface area is always essential to inhibiting the severe sintering of Pt, it is important to choose a zeolite support with a relatively large external surface area and a certain amount of acid sites after the hydrothermal aging