Stability of levetiracetam oral solution repackaged in oral plastic syringes

Purpose The long-term stability of levetiracetam solution in oral syringes was investigated in order to define a suitable beyond-use date and demonstrate the feasibility of storing prepared syringes for extended periods as an alternative to commercial levetiracetam unit dose cups. Methods Levetiracetam oral solution (100 mg/mL) was drawn into 1- and 10-mL amber polypropylene oral syringes. Triplicate samples of the syringe preparations were stored at refrigeration (2–8 °C) or room temperature (20–25 °C) and evaluated at monthly intervals for up to six months. At each time point, the samples were visually inspected and levetiracetam stability was assessed via pH measurement and high-performance liquid chromatography (HPLC). A short-term forced degradation study was conducted to confirm that the HPLC assay method was stability indicating. Results Over the six-month storage period, there was no significant change in either the visual appearance or pH of any of the levetiracetam samples. The results of serial HPLC assessment indicated that at least 97% of the initial levetiracetam concentration was retained in all samples of 1- and 10-mL oral syringes at both refrigeration and room temperature. Although this study was conducted using a generic product, the stability data obtained may be applied in repackaging decisions regarding other generic formulations of levetiracetam with similar excipient compositions. Conclusion Commercial levetiracetam 100-mg/mL oral solution was stable for up to six months in amber polypropylene oral syringes stored at both refrigeration and room temperature conditions

Using gravitational-wave standard sirens

Gravitational waves (GWs) from supermassive binary black hole (BBH) inspirals are potentially powerful standard sirens (the GW analog to standard candles) (Schutz 1986, 2002). Because these systems are well-modeled, the space-based GW observatory LISA will be able to measure the luminosity distance (but not the redshift) to some distant massive BBH systems with 1-10% accuracy. This accuracy is largely limited by pointing error: GW sources generally are poorly localized on the sky. Localizing the binary independently (e.g., through association with an electromagnetic counterpart) greatly reduces this positional error. An electromagnetic counterpart may also allow determination of the event's redshift. In this case, BBH coalescence would constitute an extremely precise (better than 1%) standard candle visible to high redshift. In practice, gravitational lensing degrades this precision, though the candle remains precise enough to provide useful information about the distance-redshift relation. Even if very rare, these GW standard sirens would complement, and increase confidence in, other standard candles.Comment: 10 pages, 8 figures. ApJ, in pres

The Parasitoid Complex of First Generation \u3ci\u3eOstrinia Nubilalis\u3c/i\u3e (Lepidoptera: Pyralidae) Larvae in Northwest Ohio

A survey of first generation European corn borer (Ostrinia nubilalis) larvae was conducted during 1997 in six cornfields located in northwestern Ohio in order to determine the larval parasitoid complex utilizing this host. Collected larvae were held under constant conditions until the larvae completed development or parasitoids emerged. The following species were recorded: Eriborus terebrans (Hymenoptera: Ichneumonidae), Macrocentrus grandii (Hymenoptera: Braconidae), Sympiesis viridula (Hymenoptera: Eulophidae), and Lixophaga sp. (Diptera: Tachinidae), Levels of parasitism in the different fields ranged from 14.3 to 83.3%. Future research will include surveys of additional fields and sampling of O. nubilalis over the entire season in the northwest Ohio region

Exploiting P2P in the Creation of Game Worlds

Peer-to-peer networks are a promising platform for supporting entirely decentralized, distributed multi-user gaming; however, multi-player games typically require highly predictable performance from the underlying network. This is at odds with the inherently unreliable nature of peer-to-peer environments. Existing approaches to providing peer-to-peer support for multi-player gaming focus on compensating for the unpredictability of the underlying network. We propose that rather than trying to compensate for these factors, they can be exploited together with information about the peer-to-peer network in order to address the problem of maintaining a novel gaming experience in the absence of a central authority. In order to explore our proposition, we model the measurable properties of P2P networks within a distributed multi-player game – NetWorld. We do this in such a way that the heterogeneous and unpredictable nature of the peer-to-peer environment becomes a positive part of the player’s experience

When the Future is not what it used to be: Lessons from the Western European Experience to Forecasting Education and Training in Transition Economies

In an era of rapid technological change, information exchange, and emergence of knowledge-intensive industries it is critical to be able to identify the future skill needs of the labour market. Growing unemployment in EU member states and pre-accession countries in Eastern Europe combined with technological changes which make the skills of a significant number of workers obsolescent each year demand adequate knowledge of medium- and long-term demand for specific skills. Some EU members states have developed employment forecasting methods to identify future skill requirements which take account of the sectoral, occupational, and educational and training factors which influence supply and demand in the labour market for skills. A number of countries in Eastern Europe which are preparing to join the EU are interested in developing employment forecasting models that would provide them with similar information relating to skills. Taking account of the requirements of the Single European Market and increasing international mobility, it is desirable that the pre-accession countries should develop models which, if possible, are comparable with existing methods of forecasting training and qualification needs in existing member states of the EU. This task requires regular medium-term forecasts which will extend the time horizon of decision makers beyond the current economic cycle, be applicable to the whole economy, allow speedy adjustment to changing circumstances, and which will take account of relevant factors such as investment plans, output and labour productivity forecasts, and technological change. The objective of this paper is to provide a summary of existing methods and data sets used to forecast education and training needs in four members of the European Union, in order to motivate similar work in three pre-accession countries. We first provide a detailed account of the different approaches to forecast education and training needs in France, Germany, Ireland and The Netherlands. For each of these countries, we consider the labour market data on which employment forecasts are based and the current methods in use, examine how data reliability and accuracy of forecasts are dealt with, and discuss the dissemination and usage of forecast information generated by those systems. We then look at the same range of issues for three pre-accession Central European countries (Czech Republic, Poland and Slovenia.) The paper concludes by suggesting a number of needed actions in preparation for developing an approach to forecasting education and training needs in the three pre-accession countries.http://deepblue.lib.umich.edu/bitstream/2027.42/39650/3/wp265.pd

Coronavirus\u27 Effect on American Christianity

The church has been losing members especially amongst its youth, but the Pew Research Center did a survey on practicing Christians and found that One-quarter of US adults overall (24%) say their faith has become stronger because of the coronavirus pandemic, while just 4% of people say their faith has become weaker. The majority has said their faith hasn’t changed much (67%) and 5% had no comment on the issue.https://ecommons.udayton.edu/roesch_symposium_content/1025/thumbnail.jp