357 research outputs found
Keeping the herds healthy and alert: implications of predator control for infectious disease
Predator control programmes are generally implemented in an attempt to increase prey population sizes. However, predator removal could prove harmful to prey populations that are regulated primarily by parasitic infections rather than by predation. We develop models for microparasitic and macroparasitic infection that specify the conditions where predator removal will (a) increase the incidence of parasitic infection, (b) reduce the number of healthy individuals in the prey population and (c) decrease the overall size of the prey population. In general, predator removal is more likely to be harmful when the parasite is highly virulent, macroparasites are highly aggregated in their prey, hosts are long-lived and the predators select infected prey
Evaluating Baculovirus as a Vector for Human Prostate Cancer Gene Therapy
Gene therapy represents an attractive strategy for the non-invasive treatment of prostate cancer, where current clinical interventions show limited efficacy. Here, we evaluate the use of the insect virus, baculovirus (BV), as a novel vector for human prostate cancer gene therapy. Since prostate tumours represent a heterogeneous environment, a therapeutic approach that achieves long-term regression must be capable of targeting multiple transformed cell populations. Furthermore, discrimination in the targeting of malignant compared to non-malignant cells would have value in minimising side effects. We employed a number of prostate cancer models to analyse the potential for BV to achieve these goals. In vitro, both traditional prostate cell lines as well as primary epithelial or stromal cells derived from patient prostate biopsies, in two- or three-dimensional cultures, were used. We also evaluated BV in vivo in murine prostate cancer xenograft models. BV was capable of preferentially transducing invasive malignant prostate cancer cell lines compared to early stage cancers and non-malignant samples, a restriction that was not a function of nuclear import. Of more clinical relevance, primary patient-derived prostate cancer cells were also efficiently transduced by BV, with robust rates observed in epithelial cells of basal phenotype, which expressed BV-encoded transgenes faster than epithelial cells of a more differentiated, luminal phenotype. Maximum transduction capacity was observed in stromal cells. BV was able to penetrate through three-dimensional structures, including in vitro spheroids and in vivo orthotopic xenografts. BV vectors containing a nitroreductase transgene in a gene-directed enzyme pro-drug therapy approach were capable of efficiently killing malignant prostate targets following administration of the pro-drug, CB1954. Thus, BV is capable of transducing a large proportion of prostate cell types within a heterogeneous 3-D prostate tumour, can facilitate cell death using a pro-drug approach, and shows promise as a vector for the treatment of prostate cancer
The Flare-energy Distributions Generated by Kink-unstable Ensembles of Zero-net-current Coronal Loops
It has been proposed that the million degree temperature of the corona is due
to the combined effect of barely-detectable energy releases, so called
nanoflares, that occur throughout the solar atmosphere. Alas, the nanoflare
density and brightness implied by this hypothesis means that conclusive
verification is beyond present observational abilities. Nevertheless, we
investigate the plausibility of the nanoflare hypothesis by constructing a
magnetohydrodynamic (MHD) model that can derive the energy of a nanoflare from
the nature of an ideal kink instability. The set of energy-releasing
instabilities is captured by an instability threshold for linear kink modes.
Each point on the threshold is associated with a unique energy release and so
we can predict a distribution of nanoflare energies. When the linear
instability threshold is crossed, the instability enters a nonlinear phase as
it is driven by current sheet reconnection. As the ensuing flare erupts and
declines, the field transitions to a lower energy state, which is modelled by
relaxation theory, i.e., helicity is conserved and the ratio of current to
field becomes invariant within the loop. We apply the model so that all the
loops within an ensemble achieve instability followed by energy-releasing
relaxation. The result is a nanoflare energy distribution. Furthermore, we
produce different distributions by varying the loop aspect ratio, the nature of
the path to instability taken by each loop and also the level of radial
expansion that may accompany loop relaxation. The heating rate obtained is just
sufficient for coronal heating. In addition, we also show that kink instability
cannot be associated with a critical magnetic twist value for every point along
the instability threshold
What is the Nature of EUV Waves? First STEREO 3D Observations and Comparison with Theoretical Models
One of the major discoveries of the Extreme ultraviolet Imaging Telescope
(EIT) on SOHO were intensity enhancements propagating over a large fraction of
the solar surface. The physical origin(s) of the so-called `EIT' waves is still
strongly debated. They are considered to be either wave (primarily fast-mode
MHD waves) or non-wave (pseudo-wave) interpretations. The difficulty in
understanding the nature of EUV waves lies with the limitations of the EIT
observations which have been used almost exclusively for their study. Their
limitations are largely overcome by the SECCHI/EUVI observations on-board the
STEREO mission. The EUVI telescopes provide high cadence, simultaneous
multi-temperature coverage, and two well-separated viewpoints. We present here
the first detailed analysis of an EUV wave observed by the EUVI disk imagers on
December 07, 2007 when the STEREO spacecraft separation was .
Both a small flare and a CME were associated with the wave cadence, and single
temperature and viewpoint coverage. These limitations are largely overcome by
the SECCHI/EUVI observations on-board the STEREO mission. The EUVI telescopes
provide high cadence, simultaneous multi-temperature coverage, and two
well-separated viewpoints. Our findings give significant support for a
fast-mode interpretation of EUV waves and indicate that they are probably
triggered by the rapid expansion of the loops associated with the CME.Comment: Solar Physics, 2009, Special STEREO Issue, in pres
Probing exotic phenomena at the interface of nuclear and particle physics with the electric dipole moments of diamagnetic atoms: A unique window to hadronic and semi-leptonic CP violation
The current status of electric dipole moments of diamagnetic atoms which
involves the synergy between atomic experiments and three different theoretical
areas -- particle, nuclear and atomic is reviewed. Various models of particle
physics that predict CP violation, which is necessary for the existence of such
electric dipole moments, are presented. These include the standard model of
particle physics and various extensions of it. Effective hadron level combined
charge conjugation (C) and parity (P) symmetry violating interactions are
derived taking into consideration different ways in which a nucleon interacts
with other nucleons as well as with electrons. Nuclear structure calculations
of the CP-odd nuclear Schiff moment are discussed using the shell model and
other theoretical approaches. Results of the calculations of atomic electric
dipole moments due to the interaction of the nuclear Schiff moment with the
electrons and the P and time-reversal (T) symmetry violating
tensor-pseudotensor electron-nucleus are elucidated using different
relativistic many-body theories. The principles of the measurement of the
electric dipole moments of diamagnetic atoms are outlined. Upper limits for the
nuclear Schiff moment and tensor-pseudotensor coupling constant are obtained
combining the results of atomic experiments and relativistic many-body
theories. The coefficients for the different sources of CP violation have been
estimated at the elementary particle level for all the diamagnetic atoms of
current experimental interest and their implications for physics beyond the
standard model is discussed. Possible improvements of the current results of
the measurements as well as quantum chromodynamics, nuclear and atomic
calculations are suggested.Comment: 46 pages, 19 tables and 16 figures. A review article accepted for
EPJ
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