18,688 research outputs found
Vertex operator algebras and operads
Vertex operator algebras are mathematically rigorous objects corresponding to
chiral algebras in conformal field theory. Operads are mathematical devices to
describe operations, that is, -ary operations for all greater than or
equal to , not just binary products. In this paper, a reformulation of the
notion of vertex operator algebra in terms of operads is presented. This
reformulation shows that the rich geometric structure revealed in the study of
conformal field theory and the rich algebraic structure of the theory of vertex
operator algebras share a precise common foundation in basic operations
associated with a certain kind of (two-dimensional) ``complex'' geometric
object, in the sense in which classical algebraic structures (groups, algebras,
Lie algebras and the like) are always implicitly based on (one-dimensional)
``real'' geometric objects. In effect, the standard analogy between
point-particle theory and string theory is being shown to manifest itself at a
more fundamental mathematical level.Comment: 16 pages. Only the definitions of "partial operad" and of "rescaling
group" have been improve
A novel two-step recombinogenic engineering method for bacterial artificial chromosome manipulation
published_or_final_versio
Scatteract: Automated extraction of data from scatter plots
Charts are an excellent way to convey patterns and trends in data, but they
do not facilitate further modeling of the data or close inspection of
individual data points. We present a fully automated system for extracting the
numerical values of data points from images of scatter plots. We use deep
learning techniques to identify the key components of the chart, and optical
character recognition together with robust regression to map from pixels to the
coordinate system of the chart. We focus on scatter plots with linear scales,
which already have several interesting challenges. Previous work has done fully
automatic extraction for other types of charts, but to our knowledge this is
the first approach that is fully automatic for scatter plots. Our method
performs well, achieving successful data extraction on 89% of the plots in our
test set.Comment: Submitted to ECML PKDD 2017 proceedings, 16 page
Live recombinant Salmonella oral vaccine against avian influenza viruses
published_or_final_versio
Helicases as antiviral drug targets.
1. We have demonstrated for the first time that the helicase of a ribonucleic acid virus, the SARS coronavirus (SARS-CoV), is a valid target for drug development. 2. Using high throughput screen and chemical synthesis, several lead compounds targeting the SARS-CoV helicase have been identified. We have shown that these compounds can inhibit SARS-CoV helicase activity and viral growth in cell culture systems. These compounds can potentially be used to target other viruses.published_or_final_versio
A hybrid adaptive antenna array
Owing to the excessive demand on signal processing and space constraint, a full digital implementation of a large adaptive antenna array at millimeter wave frequencies is very challenging. Targeted at long range high data rate point-topoint link in the 70/80 GHz bands, a novel hybrid adaptive antenna array which consists of analogue subarrays followed by a digital beamformer is presented in this paper to overcome the digital implementation difficulty. Two subarray configurations, the interleaved subarray and the side-by-side subarray, are proposed, and two Doppler resilient adaptive angle-of-arrival estimation and beamforming algorithms, the differential beam tracking (DBT) and the differential beam search (DBS), are developed. Simulation results on the DBT and DBS performance are provided using a 64 element hybrid planar array of four 4 by 4 element subarrays with the two subarray configurations, respectively. Recursive mean square error (MSE) bounds of the developed algorithms are also analyzed and compared with simulated MSEs. © 2006 IEEE
CityComfort+: A Simulation-Based Method for Predicting Mean Radiant Temperature in Dense Urban Areas
postprin
Double-stranded break can be repaired by single-stranded oligonucleotides via the ATM/ATR pathway in mammalian cells
Single-stranded oligonucleotide (SSO)-mediated gene modification is a newly developed tool for site-specific gene repair in mammalian cells; however, the corrected cells always show G2/M arrest and cannot divide to form colonies. This phenomenon and the unclear mechanism seriously challenge the future application of this technique. In this study, we developed an efficient SSO-mediated DNA repair system based on double-stranded break (DSB) induction. We generated a mutant EGFP gene with insertions of 24 bp to 1.6 kb in length as a reporter integrated in mammalian cell lines. SSOs were successfully used to delete the insertion fragments upon DSB induction at a site near the insertion. We demonstrated that this process is dependent on the ATM/ATR pathway. Importantly, repaired cell clones were viable. Effects of deletion length, SSO length, strand bias, and SSO modification on gene repair frequency were also investigated. © 2008 Mary Ann Liebert, Inc.published_or_final_versio
Determination of the functions of the putative metal-binding domain of the SCV helicase.
published_or_final_versio
Treating phenotype as given: a simple resampling method for genome-wide association studies
Significance of genetic association to a marker has been traditionally evaluated through statistics that are standardized such that their null distributions conform to some known ones. Distributional assumptions are often required in this standardization procedure. Based on the observation that the phenotype remains the same regardless of the marker being investigated, we propose a simple statistic that does not need such standardization. We propose a resampling procedure to assess this statistic’s genome-wide significance. This method has been applied to replicate 2 of the Genetic Analysis Workshop 17 simulated data on unrelated individuals in an attempt to map phenotype Q2. However, none of the selected SNPs are in genes that are disease-causing. This may be due to the weak effect that each genetic factor has on Q2
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