Leave and financial support for family caregivers in EU member states

This report shows which forms of long-term leave exist in several EU member states for family caregivers who care for a dependent relative at home. It also shows, whether there is some form of financial benefit available for the caregiver during the leave. The support arrangements of 14 member states of the European Union (EU) are presented in brief descriptions and overview tables

Freistellungen und finanzielle Leistungen zur häuslichen Pflege in europäischen Mitgliedstaaten

Die vorliegende Übersicht stellt dar, welche Formen einer längerfristigen Freistellung für die häusliche Pflege von Angehörigen in ausgewählten EU-Mitgliedstaaten bestehen und ob es für die Phase der Pflege eine finanzielle Leistung für die pflegende Person gibt. Es werden die gesetzlichen Regelungen aus 14 EU-Mitgliedstaaten in Form von Kurzbeschreibungen und Übersichtstabellen vorgestellt

Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.

Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is needed for understanding skewed immune responses and defining predictors of outcome. Here, we performed a longitudinal multi-omics study using a two-center cohort of 14 patients. We analyzed the bulk transcriptome, bulk DNA methylome, and single-cell transcriptome (>358,000 cells, including BCR profiles) of peripheral blood samples harvested from up to 5 time points. Validation was performed in two independent cohorts of COVID-19 patients. Severe COVID-19 was characterized by an increase of proliferating, metabolically hyperactive plasmablasts. Coinciding with critical illness, we also identified an expansion of interferon-activated circulating megakaryocytes and increased erythropoiesis with features of hypoxic signaling. Megakaryocyte- and erythroid-cell-derived co-expression modules were predictive of fatal disease outcome. The study demonstrates broad cellular effects of SARS-CoV-2 infection beyond adaptive immune cells and provides an entry point toward developing biomarkers and targeted treatments of patients with COVID-19