Archaeological signatures of landscape and settlement change on the Isle of Harris

Between 2004 and 2011, a programme of archaeological investigation by the University of Birmingham on the Isle of Harris, a distinctive island forming part of the Western Isles of Scotland, has allowed the archaeological remains of this enigmatic place to be further characterised and understood. Despite intensive archaeological interest in the archipelago for a number of decades, the Isle of Harris has been overlooked and only now are we beginning to identify the archaeological resource and make comparisons to the wealth of published data from islands such as the Uists, Barra and Lewis. This paper highlights some generic overall patterns of archaeological signatures on the Isle which has been identified through a range of archaeological methods including field walking, intrusive excavation, aerial reconnaissance, geophysical and topographical survey, and documentary research. Several key case studies will be introduced including upland shieling complexes and mulitperiod settlement sites on the west coast machair systems. The purpose of the paper is not to present a gazetteer of the results of the work to date, but to highlight some of the key findings with a view to demonstrating that the Isle of Harris is directly comparable with the archaeologically rich landscapes of the other islands

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Luminescence dating of aeolian sands from archaeological sites in Northern Britain: a preliminary study

Luminescence dating of aeolian sands from archaeological sites has potential to contribute to regional chronologies for sediment deposition and to provide a greater understanding of climatic influences on early communities. The Northern and Western Isles of Scotland provide important opportunities for sampling archaeologically intercalated sands for these purposes, and to provide constrained samples for method validation. A wide range of modern beaches have been sampled in the Western and Orkney Isles of Scotland to examine regional variations in luminescence sensitivity, residuals and ease of bleaching. These modern sands have negligible residuals for infra-red stimulated luminescence (IRSL), small optically stimulated luminescence (OSL) residuals and significant thermoluminescence residuals. The relationship between these signals and laboratory bleaching results may indicate the initial depositional environment, and hence lead to a means of identifying well-bleached dating samples. Both sensitivities and residuals show regional differences, reflecting local geology. Preliminary ages obtained from aeolian sands associated with archaeological sites at Amble (Northumbria) and Tofts Ness (Sanday, Orkney) using regenerative blue OSL techniques on extracted quartz are broadly consistent with external age controls from the first and third millennium BC

Radiocarbon evidence for the Lateglacial human recolonisation of Northern Europe

This paper examines, through the use of Accelerator Mass Spectrometry dating, the database of Lateglacial cultures involved in the recolonisation of northern Europe. The aim is not only to determine the timing of that recolonisation, but also to propose a general model of hunter-gatherer colonisation at a sub-continental scale. The question is addressed of how long the period of abandonment of northern Europe during the Würm/Weichsel glaciation may have lasted, and when it both started and came to an end. A series of questions is asked concerning the processes and mechanics of recolonisation and the sequences for specific areas are examined. AMS radiocarbon dating shows that a two stage process was involved, which has important implications for our analysis of regional settlement patterns and the changing scale of Lateglacial hunting systems. Recolonisation was a dynamic process, integral to, and internally driven by, the social life of Lateglacial hunters. It may have been constrained by environmental and resource factors, which we have emphasised here, but ultimately it was an historical, social process and should be similarly regarded to that of the farmers. By measuring rates of expansion data are provided for use in other studies of hunter-gatherer colonisation

Survey of Palaeolithic sites by luminescence profiling, a case study from Eastern Europe

A luminescence-based approach to the rapid characterisation of sites in terms of their datability and sedimentary history is described (luminescence profiling), and contrasting results presented for three Palaeolithic archaeological sites in Russia. Three mineral/grain-size fractions (polymineral silt-sized, polymineral sand-sized, quartz-enriched sand-sized) were separated from each of many small samples taken through the sites’ stratigraphies. Luminescence signals from the different fractions were measured using infra-red light, blue light, and thermal stimulation. Patterns in luminescence sensitivity and equivalent dose values are used to indicate which sites, samples, fractions and/or signals may yield meaningful luminescence ages, and the experimental effort that may be required to obtain said ages. Case studies range from a site where a detailed chronostratigraphy might be produced using a limited number of full luminescence dates to tie in the profiling results, to a site where profiling indicates there is little chance of producing useful luminescence dates. These interpretations are based on dialogue between the luminescence profiling results and archaeological, palaeoenvironmental, and geomorphological evidence. Luminescence profiling is shown to be a useful tool for understanding sedimentological process at each site, independent of full luminescence dating.</p