Fe(HSO₄ )₃ /SiO₂: an efficient and heterogeneous catalyst for one-pot synthesis of 2-aryl-chromene-4-ones (flavanones)

<div><p>Silica ferric hydrogensulphate is an efficient heterogeneous catalyst for cyclisation of 2-hydroxychalcones to their corresponding flavanones (chromanone). This intramolecular oxa-Michael reaction was carried out in high yields in the presence of electron donating and electron withdrawing groups in the chalcone structure. Also, we found that aniline can act as an organic co-catalyst in direct synthesis of flavanones from 2-hydroxyacethophenone and aldehydes in the presence of Fe(HSO₄)₃/SiO₂. Flavanones were prepared in high yields in a new catalytic system with similar substituted effect in the indirect cyclisation method. The catalyst in all the above reactions is reusable without significant decreases in its activity after four times of recycling.</p></div

sj-docx-1-chl-10.1177_17475198231223679 – Supplemental material for Ortho-iodination of aromatic carboxylic acids in aqueous media

Supplemental material, sj-docx-1-chl-10.1177_17475198231223679 for Ortho-iodination of aromatic carboxylic acids in aqueous media by Hengameh Havasel, Roghaye Soltani, Hossein Eshghi and Arash Ghaderi in Journal of Chemical Research</p

Pure Water-Induced Dehalogenation of 2,4-Di-<i>tert</i>-amino-6-substituted-5-halogenopyrimidines

Dehalogenation of 5-halogenopyrimidine derivatives in boiling pure water was accomplished in high yields. The substrate and pure water are the only two reaction components in this process. Dehalogenation takes place in the absence of any catalysts, additives, basic, or acidic conditions, introducing water as a potential dehalogenation reagent

Benzimidazolium dicationic ionic liquid as an efficient and reusable catalyst for the synthesis of α-aminophosphonates and bis (α-aminophosphonates) under solvent-free condition

<div><p>GRAPHICAL ABSTRACT</p><p></p></div

Synthesis, characterization, and application of [1-methylpyrrolidin-2-one-SO₃H]Cl as an efficient catalyst for the preparation of α-aminophosphonate and docking simulation of ligand bond complexes of cyclin-dependent kinase 2

<p>A sulfonic acid functionalized ionic liquid was designed, synthesized and successfully used as a Brønsted acid catalyst for the one-pot synthesis of α-aminophosphonates containing benzothiazole at room temperature under solvent-free conditions in excellent yields. The advantages of this method are the reusability of the catalyst, high conversion, short reaction time, and simple experimental procedure. A computer modeling and docking simulation of ligand bond complexes of cyclin-dependent kinase 2 are presented. The results indicate that diethyl ((4-(dimethylamino) phenyl) ((6-nitrobenzo[<i>d</i>]thiazol-2-yl) amino)methyl)phosphonate was found to be the best selective inhibitor of cyclin-dependent kinase 2.</p

Synthesis of pyrimido[4′,5′:5,6][1,4]dithiepino[2,3-b]quinoxalines: Derivatives of a novel seven membered ring system

<p></p> <p>A convenient and efficient procedure for the synthesis of tetracyclic dithiepin derivatives is described through the condensation reaction of 2,4-dichloro-5-(chloromethyl)-6- methylpyrimidine and quinoxaline-2,3-dithiol followed by treatment with secondary amines.</p

Synthesis of 2-substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-<i>b</i>]quinoxaline as a new heterocyclic system

<p></p> <p>2-Substituted-4-methyl-5,13-dihydropyrimido[4′,5′:5,6][1,4]thiazepino[2,3-<i>b</i>]quinoxalines (<b>7a-g</b>), derivatives of a new heterocyclic system were synthesized through cyclocondensation of 2,4-dichloro-5-(chloromethyl)-6-methylpyrimidine (<b>3</b>) with 3-aminoquinoxaline-2-thiol (<b>4</b>) and subsequent substitution by various secondary amines. Regioselective heterocyclization was confirmed by X-ray crystallographic analysis for 4-methyl-2-(pyrrolidin-1-yl)-5,13-dihydropyrimido[4′,5′:5,6] [1,4]thiazepino[2,3-<i>b</i>]quinoxaline <b>(7a).</b></p